OBJECTIVE: To determine whether chronic hyperglycemia causes increased levels of serum tumor necrosis factor (TNF) and interleukin 1 alpha (IL-1 alpha) and IL-1 beta. RESEARCH DESIGN AND METHODS: Sera were obtained from 59 diabetic patients, 44 chronically ill nondiabetic patients, and 34 age-matched healthy control subjects. Mononuclear cells were isolated from a subgroup of diabetic patients and healthy control subjects. RESULTS: Except for a modest increase in the prevalence of detectable serum TNF levels in diabetic patients, the serum cytokines measured in this study did not appear to be altered in diabetes. In vitro TNF production by mononuclear cells was not altered in diabetic patients. However, in vitro IL-1 beta secretion, in response to lipopolysaccharides, was reduced. CONCLUSIONS: Diabetes mellitus is not associated with significant changes in serum levels of TNF, IL-1 alpha, or IL-1 beta. In vitro secretion of IL-1 beta in response to lipopolysaccharides may be reduced in diabetes.
OBJECTIVE: To determine whether chronic hyperglycemia causes increased levels of serum tumor necrosis factor (TNF) and interleukin 1 alpha (IL-1 alpha) and IL-1 beta. RESEARCH DESIGN AND METHODS: Sera were obtained from 59 diabeticpatients, 44 chronically ill nondiabeticpatients, and 34 age-matched healthy control subjects. Mononuclear cells were isolated from a subgroup of diabeticpatients and healthy control subjects. RESULTS: Except for a modest increase in the prevalence of detectable serum TNF levels in diabeticpatients, the serum cytokines measured in this study did not appear to be altered in diabetes. In vitro TNF production by mononuclear cells was not altered in diabeticpatients. However, in vitro IL-1 beta secretion, in response to lipopolysaccharides, was reduced. CONCLUSIONS:Diabetes mellitus is not associated with significant changes in serum levels of TNF, IL-1 alpha, or IL-1 beta. In vitro secretion of IL-1 beta in response to lipopolysaccharides may be reduced in diabetes.
Authors: M J Hussain; M Peakman; H Gallati; S S Lo; M Hawa; G C Viberti; P J Watkins; R D Leslie; D Vergani Journal: Diabetologia Date: 1996-01 Impact factor: 10.122
Authors: Anne Sofie Andreasen; Theis Pedersen-Skovsgaard; Ronan M G Berg; Kira Dynnes Svendsen; Bo Feldt-Rasmussen; Bente K Pedersen; Kirsten Møller Journal: Intensive Care Med Date: 2010-03-13 Impact factor: 17.440
Authors: E Lachmandas; K Thiem; C van den Heuvel; A Hijmans; B E de Galan; C J Tack; M G Netea; R van Crevel; J A van Diepen Journal: Eur J Clin Microbiol Infect Dis Date: 2017-11-30 Impact factor: 3.267