| Literature DB >> 19914289 |
Shuxiong Xu1, Zhaolin Sun, Lian Li, Jun Liu, Jian He, Dalong Song, Gang Shan, Hong Liu, Xiongfei Wu.
Abstract
VSIG4 has been recently described as a B7 family-related protein. The immunotherapeutic potential of dendritic cells (DCs) transfected with VSIG4 recombinant adenovirus has not been characterized. In the present study, DCs were transfected with human VSIG4 (hVSIG4) recombinant adenovirus, a novel costimulatory molecule known to be a potent inhibitor of T cell activation. Transfected DCs were cocultured with allogeneic T cells and proliferation, cytokine production and T cell activation marker expression were assessed. The results showed that T cell proliferation potential, cytokine production and activation marker expression were suppressed after coculture with hVSIG4 recombinant adenovirus-transfected DCs. These findings suggest that DCs transfected with hVSIG4 recombinant adenovirus are capable of inducing allogeneic T cell suppression, which represents an ideal strategy for manipulating the immune response to transplanation or autoimmune diseases.Entities:
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Year: 2009 PMID： 19914289 DOI： 10.1016/j.imlet.2009.11.003
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685