| Literature DB >> 19914158 |
Thomas J Takara1, Stephen P Bell.
Abstract
The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.Entities:
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Year: 2009 PMID： 19914158 DOI： 10.1016/j.cell.2009.10.037
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582