Literature DB >> 19914109

Heritability of syringomyelia in Cavalier King Charles spaniels.

Tom Lewis1, Clare Rusbridge, Penny Knowler, Sarah Blott, John A Woolliams.   

Abstract

Mixed model analysis of 384 Cavalier King Charles spaniels (CKCS), with a magnetic resonance imaging diagnosis for the presence or absence of a syrinx, in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007, revealed a moderately high estimate of heritability of syringomyelia (h(2)=0.37+/-0.15 standard error) when analysed as a binary trait. Inspection of cases where the disease segregated within families pointed to genes at more than one locus influencing syringomyelia. The availability of estimated breeding values for Kennel Club registered CKCS is a significant step in being able to select against syringomyelia, particularly given the difficulty of ascertaining the disease phenotype. 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19914109     DOI： 10.1016/j.tvjl.2009.10.022

Source DB:  PubMed          Journal:  Vet J        ISSN： 1090-0233            Impact factor:   2.688


  11 in total

1.  Increase in cerebellar volume in Cavalier King Charles Spaniels with Chiari-like malformation and its role in the development of syringomyelia.

Authors:  Thomas A Shaw; Imelda M McGonnell; Colin J Driver; Clare Rusbridge; Holger A Volk
Journal:  PLoS One       Date:  2012-04-10       Impact factor: 3.240

2.  Craniometric Analysis of the Hindbrain and Craniocervical Junction of Chihuahua, Affenpinscher and Cavalier King Charles Spaniel Dogs With and Without Syringomyelia Secondary to Chiari-Like Malformation.

Authors:  Susan P Knowler; Anna-Mariam Kiviranta; Angus K McFadyen; Tarja S Jokinen; Roberto M La Ragione; Clare Rusbridge
Journal:  PLoS One       Date:  2017-01-25       Impact factor: 3.240

3.  A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels.

Authors:  Frédéric Ancot; Philippe Lemay; Susan P Knowler; Karen Kennedy; Sandra Griffiths; Giunio Bruto Cherubini; Jane Sykes; Paul J J Mandigers; Guy A Rouleau; Clare Rusbridge; Zoha Kibar
Journal:  BMC Genet       Date:  2018-03-22       Impact factor: 2.797

4.  Twelve years of chiari-like malformation and syringomyelia scanning in Cavalier King Charles Spaniels in the Netherlands: Towards a more precise phenotype.

Authors:  Katrien Wijnrocx; Leonie W L Van Bruggen; Wieteke Eggelmeijer; Erik Noorman; Arnold Jacques; Nadine Buys; Steven Janssens; Paul J J Mandigers
Journal:  PLoS One       Date:  2017-09-21       Impact factor: 3.240

5.  Biopsy and histologic findings of the dura mater at the level of the foramen magnum in 121 CKCS with Chiari-like malformation.

Authors:  Jaclyn P Holdsworth; Dominic J Marino; Catherine A Loughin; Andrew D Miller; Joseph J Sackman; Martin L Lesser; Marissa O'Donnell
Journal:  Front Vet Sci       Date:  2022-09-07

6.  Changes over time in craniocerebral morphology and syringomyelia in cavalier King Charles spaniels with Chiari-like malformation.

Authors:  Colin J Driver; Luisa De Risio; Sarah Hamilton; Clare Rusbridge; Ruth Dennis; Imelda M McGonnell; Holger A Volk
Journal:  BMC Vet Res       Date:  2012-11-08       Impact factor: 2.741

7.  Quantitative trait loci (QTL) study identifies novel genomic regions associated to Chiari-like malformation in Griffon Bruxellois dogs.

Authors:  Philippe Lemay; Susan P Knowler; Samir Bouasker; Yohann Nédélec; Simon Platt; Courtenay Freeman; Georgina Child; Luis B Barreiro; Guy A Rouleau; Clare Rusbridge; Zoha Kibar
Journal:  PLoS One       Date:  2014-04-16       Impact factor: 3.240

8.  Inheritance of Chiari-Like Malformation: Can a Mixed Breeding Reduce the Risk of Syringomyelia?

Authors:  Susan P Knowler; Henny v/d Berg; Angus McFadyen; Roberto M La Ragione; Clare Rusbridge
Journal:  PLoS One       Date:  2016-03-23       Impact factor: 3.240

9.  Prevalence and heritability of symptomatic syringomyelia in Cavalier King Charles Spaniels and long-term outcome in symptomatic and asymptomatic littermates.

Authors:  M S Thøfner; C L Stougaard; U Westrup; A A Madry; C S Knudsen; H Berg; C S E Jensen; R M L Handby; H Gredal; M Fredholm; M Berendt
Journal:  J Vet Intern Med       Date:  2014-10-10       Impact factor: 3.333

10.  Medical infrared thermal imaging of syringomyelia in the Cavalier King Charles Spaniel.

Authors:  M Larkin; C Loughin; D Marino; C Dewey; S Umbaugh; J Sackman
Journal:  BMC Vet Res       Date:  2020-05-14       Impact factor: 2.741
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