| Literature DB >> 19913904 |
Maria Cristina Fossi1, Jorge Urban, Silvia Casini, Silvia Maltese, Giacomo Spinsanti, Cristina Panti, Serena Porcelloni, Simone Panigada, Giancarlo Lauriano, Carlos Niño-Torres, Lorenzo Rojas-Bracho, Begoña Jimenez, Juan Muñoz-Arnanz, Letizia Marsili.
Abstract
The main objective of this study was to apply a set of sensitive non-lethal biomarkers in skin biopsies of fin whales (Balaenoptera physalus) to evaluate the toxicological status of this mysticete in the Pelagos Sanctuary (Mediterranean Sea) and in the Gulf of California (Sea of Cortez-Mexico). We developed a "multi-trial diagnostic tool" (based on field and in vitro studies), combining molecular biomarkers (western blot of CYP1A1, CYP2B) and gene expression (qRT-PCR of HSP70, ERα, AHR, E2F-1) with the analysis of OCs, PAHs and PBDEs. The study revealed a higher level of toxicological stress in the Mediterranean fin whales.Entities:
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Year: 2009 PMID： 19913904 DOI： 10.1016/j.marenvres.2009.10.006
Source DB: PubMed Journal: Mar Environ Res ISSN： 0141-1136 Impact factor: 3.130