OBJECTIVES: Both leptin and ghrelin (in the forms of acyl ghrelin and des-acyl ghrelin) are involved in food intake, and appear to be dysregulated in chronic kidney disease. This study describes plasma leptin, acyl, and des-acyl ghrelin concentrations in relation to protein intake and body mass index (BMI) in hemodialysis (HD) patients. DESIGN: This was a cross-sectional study. SETTING: This study was conducted during the baseline phase of the French multicenter Influence of a High-Flux Dialyzer on Long-Term Leptin Levels Study. PATIENTS: We studied 125 HD patients (aged 72.5+/-11.7 years; 59% males). MAIN OUTCOME MEASURE: Blood samples were collected during fasting, and before a regular HD session. Plasma ghrelin and leptin were evaluated. The protein equivalents of total nitrogen appearance and BMI were calculated. RESULTS: Patients demonstrated elevated serum leptin (48.0+/-49.0 ng/mL) and des-acyl ghrelin (646.6+/-489.5 pg/mL) levels, and low acyl ghrelin levels (29.8+/-58.5 pg/mL), according to normal values. Acyl ghrelin was negatively correlated with C-reactive protein (r=-0.34, P < .001). The des-acyl to acyl ghrelin ratio was negatively correlated with protein intake, as estimated by normalized Protein Nitrogen Appearance (r=-0.22, P=.01). Serum leptin exhibited its well-described positive correlation with BMI and waist circumference, but the other hormones did not. CONCLUSIONS: This study reports high des-acyl ghrelin and leptin levels and low acyl ghrelin levels in HD patients, a finding potentially associated with inflammation and food intake.
OBJECTIVES: Both leptin and ghrelin (in the forms of acyl ghrelin and des-acyl ghrelin) are involved in food intake, and appear to be dysregulated in chronic kidney disease. This study describes plasma leptin, acyl, and des-acyl ghrelin concentrations in relation to protein intake and body mass index (BMI) in hemodialysis (HD) patients. DESIGN: This was a cross-sectional study. SETTING: This study was conducted during the baseline phase of the French multicenter Influence of a High-Flux Dialyzer on Long-Term Leptin Levels Study. PATIENTS: We studied 125 HDpatients (aged 72.5+/-11.7 years; 59% males). MAIN OUTCOME MEASURE: Blood samples were collected during fasting, and before a regular HD session. Plasma ghrelin and leptin were evaluated. The protein equivalents of total nitrogen appearance and BMI were calculated. RESULTS:Patients demonstrated elevated serum leptin (48.0+/-49.0 ng/mL) and des-acyl ghrelin (646.6+/-489.5 pg/mL) levels, and low acyl ghrelin levels (29.8+/-58.5 pg/mL), according to normal values. Acyl ghrelin was negatively correlated with C-reactive protein (r=-0.34, P < .001). The des-acyl to acyl ghrelin ratio was negatively correlated with protein intake, as estimated by normalized Protein Nitrogen Appearance (r=-0.22, P=.01). Serum leptin exhibited its well-described positive correlation with BMI and waist circumference, but the other hormones did not. CONCLUSIONS: This study reports high des-acyl ghrelin and leptin levels and low acyl ghrelin levels in HDpatients, a finding potentially associated with inflammation and food intake.
Authors: Crina Claudia Rusu; Simona Racasan; Diana Moldovan; Alina Potra; Dacian Tirinescu; Cristian Budurea; Remus Orasan; Ioan Mihai Patiu; Cosmina Bondor; Dan Vladutiu; Dan Delean; Alexandra Danu; Ina Maria Kacso Journal: Int Urol Nephrol Date: 2018-07-13 Impact factor: 2.370
Authors: Gary C H Gan; Aditya Bhat; Henry H L Chen; Kennith H Gu; Fernando Fernandez; Krishna K Kadappu; Karen Byth; Suzanne Eshoo; Liza Thomas Journal: J Am Heart Assoc Date: 2020-12-29 Impact factor: 5.501
Authors: Maurice Dungey; Katherine L Hull; Alice C Smith; James O Burton; Nicolette C Bishop Journal: Int J Endocrinol Date: 2013-05-13 Impact factor: 3.257