| Literature DB >> 1991321 |
A O Wilkie1, D R Higgs, K A Rack, V J Buckle, N K Spurr, N Fischel-Ghodsian, I Ceccherini, W R Brown, P C Harris.
Abstract
We have completed a long-range restriction map of the terminal region of the short arm of human chromosome 16 (16p13.3) by physically linking a distal genetic locus (alpha-globin) with two recently isolated probes to telomere-associated repeats (TelBam3.4 and TelBam-11). Comparison of 47 chromosomes has revealed major polymorphic length variation in this region: we have identified three alleles in which the alpha-globin genes lie 170 kb, 350 kb, or 430 kb from the telemere. The two most common alleles contain different terminal segments, starting 145 kb distal to the alpha-globin genes. Beyond this boundary these alleles are nonhomologous, yet each contains sequences related to other (different) chromosome termini. This chromosome size polymorphism has probably arisen by occasional exchanges between the subtelomeric regions of nonhomologous chromosomes; analogous length variation is likely to be present at other human telomeres.Entities:
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Year: 1991 PMID： 1991321 DOI： 10.1016/0092-8674(91)90243-r
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582