Literature DB >> 19912808

Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene.

A F Seasholtz1, F J Bourbonais, C E Harnden, S A Camper.   

Abstract

The mouse corticotropin-releasing hormone (CRH) gene has been isolated and characterized by DNA sequence analysis. The gene exhibits a structural organization similar to that of the human, rat, and ovine genes with two exons and an intervening sequence of 675 base pairs interrupting the 5' untranslated sequence of the mature mRNA. Analysis of the nucleotide sequence reveals that the mouse CRH peptide is identical at the amino acid level to the human and rat CRH peptides, with only three nucleotide changes between the rat and mouse sequences within the CRH peptide-encoding region. Additionally, the mouse CRH gene exhibits greater than 92% homology to the rat, human, and ovine CRH genes within the first 336 nucleotides of 5' flanking DNA, suggesting that this sequence contains important transcriptional control elements which have been conserved across species to mediate the regulation of this important neuroendocrine peptide. The expression of the mouse CRH gene in brain is demonstrated using in situ hybridization analysis. Mouse CRH mRNA can be detected in the paraventricular nucleus of the hypothalamus and inferior olivary nucleus of mouse brain.

Entities:  

Year:  1991        PMID： 19912808     DOI： 10.1016/1044-7431(91)90054-r

Source DB:  PubMed          Journal:  Mol Cell Neurosci        ISSN： 1044-7431            Impact factor:   4.314


  10 in total

1.  Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgery.

Authors:  Lixin Wang; Miriam Goebel-Stengel; Andreas Stengel; S Vincent Wu; Gordon Ohning; Yvette Taché
Journal:  Brain Res       Date:  2011-07-23       Impact factor: 3.252

2.  Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice.

Authors:  I J Karolyi; H L Burrows; T M Ramesh; M Nakajima; J S Lesh; E Seong; S A Camper; A F Seasholtz
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

3.  Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH.

Authors:  S C Weninger; A J Dunn; L J Muglia; P Dikkes; K A Miczek; A H Swiergiel; C W Berridge; J A Majzoub
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

4.  Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants.

Authors:  Eleni Goshu; Hui Jin; Rachel Fasnacht; Mike Sepenski; Jacques L Michaud; Chen-Ming Fan
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

5.  The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.

Authors:  Daniela Cota; Giovanni Marsicano; Matthias Tschöp; Yvonne Grübler; Cornelia Flachskamm; Mirjam Schubert; Dorothee Auer; Alexander Yassouridis; Christa Thöne-Reineke; Sylvia Ortmann; Federica Tomassoni; Cristina Cervino; Enzo Nisoli; Astrid C E Linthorst; Renato Pasquali; Beat Lutz; Günter K Stalla; Uberto Pagotto
Journal:  J Clin Invest       Date:  2003-08       Impact factor: 14.808

6.  Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.

Authors:  J L Michaud; T Rosenquist; N R May; C M Fan
Journal:  Genes Dev       Date:  1998-10-15       Impact factor: 11.361

7.  Corticotropin-releasing hormone (Crh) maps to mouse chromosome 3.

Authors:  L T Knapp; C E Keegan; A F Seasholtz; S A Camper
Journal:  Mamm Genome       Date:  1993       Impact factor: 2.957

8.  Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice.

Authors:  Kyle D Ketchesin; Gwen S Stinnett; Audrey F Seasholtz
Journal:  Alcohol Clin Exp Res       Date:  2016-07-04       Impact factor: 3.455

9.  Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract.

Authors:  Roeland Buckinx; Dirk Adriaensen; Luc Van Nassauw; Jean-Pierre Timmermans
Journal:  Front Neurosci       Date:  2011-04-20       Impact factor: 4.677

10.  Corticotropin-Releasing Hormone (CRH) Promotes Macrophage Foam Cell Formation via Reduced Expression of ATP Binding Cassette Transporter-1 (ABCA1).

Authors:  Wonkyoung Cho; Jihee Lee Kang; Young Mi Park
Journal:  PLoS One       Date:  2015-06-25       Impact factor: 3.240
  10 in total

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