AIMS: To evaluate the relationship between microvessel density assessed by endoglin expression and the molecular subtypes of human invasive breast carcinomas and whether there is evidence to indicate that angiogenesis could be a putative target for therapy in specific subsets of breast cancer. METHODS AND RESULTS: We studied a series of 161 breast carcinomas, but information was available on only 142 tumours. We correlated endoglin expression with distinct breast carcinoma subgroups classified according to immunohistochemical profiling. Additionally, we compared it with other biomarkers for the aggressive basal-like subset and with available histopathological data. Although the basal-like subtype has higher microvessel density, there are no significant differences with the other molecular subtypes of breast cancer. CONCLUSIONS: This study found no significant differences in tumour vascularity in different molecular subtypes of breast cancer.
AIMS: To evaluate the relationship between microvessel density assessed by endoglin expression and the molecular subtypes of humaninvasive breast carcinomas and whether there is evidence to indicate that angiogenesis could be a putative target for therapy in specific subsets of breast cancer. METHODS AND RESULTS: We studied a series of 161 breast carcinomas, but information was available on only 142 tumours. We correlated endoglin expression with distinct breast carcinoma subgroups classified according to immunohistochemical profiling. Additionally, we compared it with other biomarkers for the aggressive basal-like subset and with available histopathological data. Although the basal-like subtype has higher microvessel density, there are no significant differences with the other molecular subtypes of breast cancer. CONCLUSIONS: This study found no significant differences in tumour vascularity in different molecular subtypes of breast cancer.
Authors: Marius G Pakalniskis; Wendy A Wells; Mary C Schwab; Heather M Froehlich; Shudong Jiang; Zhongze Li; Tor D Tosteson; Steven P Poplack; Peter A Kaufman; Brian W Pogue; Keith D Paulsen Journal: Radiology Date: 2011-03-15 Impact factor: 11.105
Authors: Marta Tiburcio; Sandra M A Costa; Maria DE Fatima Duarte; Fernando C Schmitt; Adhemar Longatto Filho Journal: Oncol Lett Date: 2012-07-17 Impact factor: 2.967
Authors: Valgardur Sigurdsson; Bylgja Hilmarsdottir; Hekla Sigmundsdottir; Agla J R Fridriksdottir; Markus Ringnér; Rene Villadsen; Ake Borg; Bjarni A Agnarsson; Ole William Petersen; Magnus K Magnusson; Thorarinn Gudjonsson Journal: PLoS One Date: 2011-09-06 Impact factor: 3.240
Authors: François Pepin; Nicholas Bertos; Julie Laferrière; Svetlana Sadekova; Margarita Souleimanova; Hong Zhao; Greg Finak; Sarkis Meterissian; Michael T Hallett; Morag Park Journal: Breast Cancer Res Date: 2012-08-20 Impact factor: 6.466