Literature DB >> 19912223

Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?

Pierre-Emmanuel Morange1, David-Alexandre Tregouet.   

Abstract

Venous thromboembolism (VTE) is a frequent disease that has a major genetic component of risk. However, known identified genetic risk factors account for <30% of idiopathic (without any environmental origin) VTE cases. This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state-of-art methods and discuss promising themes for finding new susceptibility loci.

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Year:  2009        PMID： 19912223     DOI： 10.1111/j.1365-2141.2009.07975.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  6 in total

1.  A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1.

Authors:  Pierre-Emmanuel Morange; Irene Bezemer; Noémie Saut; Lance Bare; Gwenaelle Burgos; Jessy Brocheton; Hervé Durand; Christine Biron-Andreani; Jean-Francois Schved; Gilles Pernod; Pilar Galan; Ludovic Drouet; Diana Zelenika; Marine Germain; Viviane Nicaud; Simon Heath; Ewa Ninio; Aurélien Delluc; Thomas Münzel; Tanja Zeller; Stefan-Martin Brand-Herrmann; Marie-Christine Alessi; Laurence Tiret; Mark Lathrop; François Cambien; Stefan Blankenberg; Joseph Emmerich; David-Alexandre Trégouët; Frits R Rosendaal
Journal:  Am J Hum Genet       Date:  2010-03-11       Impact factor: 11.025

2.  C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies.

Authors:  Alfonso Buil; David-Alexandre Trégouët; Juan Carlos Souto; Noémie Saut; Marine Germain; Maxime Rotival; Laurence Tiret; Françcois Cambien; Mark Lathrop; Tanja Zeller; Marie-Christine Alessi; Santiago Rodriguez de Cordoba; Thomas Münzel; Philipp Wild; Jordi Fontcuberta; France Gagnon; Joseph Emmerich; Laura Almasy; Stefan Blankenberg; José-Manuel Soria; Pierre-Emmanuel Morange
Journal:  Blood       Date:  2010-03-08       Impact factor: 22.113

3.  Linkage analysis combined with whole-exome sequencing identifies a novel prothrombin (F2) gene mutation in a Dutch Caucasian family with unexplained thrombosis.

Authors:  René Mulder; Ton Lisman; Joost C M Meijers; James A Huntington; André B Mulder; Karina Meijer
Journal:  Haematologica       Date:  2019-10-03       Impact factor: 9.941

4.  Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes.

Authors:  Luca A Lotta; Mark Wang; Jin Yu; Ida Martinelli; Fuli Yu; Serena M Passamonti; Dario Consonni; Emanuela Pappalardo; Marzia Menegatti; Steven E Scherer; Lora L Lewis; Humeira Akbar; Yuanqing Wu; Matthew N Bainbridge; Donna M Muzny; Pier M Mannucci; Richard A Gibbs; Flora Peyvandi
Journal:  BMC Med Genomics       Date:  2012-02-21       Impact factor: 3.063

5.  Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project.

Authors:  Laura Martin-Fernandez; Andrey Ziyatdinov; Marina Carrasco; Juan Antonio Millon; Angel Martinez-Perez; Noelia Vilalta; Helena Brunel; Montserrat Font; Anders Hamsten; Juan Carlos Souto; José Manuel Soria
Journal:  PLoS One       Date:  2016-01-19       Impact factor: 3.240

6.  A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.

Authors:  Nicolas Greliche; Marine Germain; Jean-Charles Lambert; William Cohen; Marion Bertrand; Anne-Marie Dupuis; Luc Letenneur; Mark Lathrop; Philippe Amouyel; Pierre-Emmanuel Morange; David-Alexandre Trégouët
Journal:  BMC Med Genet       Date:  2013-03-20       Impact factor: 2.103
  6 in total

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