Literature DB >> 19911824

Anhydrous hydration of nitriles to amides using aldoximes as the water source.

Jinwoo Lee1, Min Kim, Sukbok Chang, Hee-Yoon Lee.   

Abstract

Anhydrous hydrolysis of nitriles to amides was developed using acetaldoxime as the water source in the presence of Rh catalyst. Conversion of various nitriles to amides was performed under neutral and anhydrous conditions, and the reaction displays excellent compatibility with acid or base labile and hydrolytically labile functional groups.

Entities:  

Year:  2009        PMID： 19911824     DOI： 10.1021/ol902309z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Total Synthesis of Pentacyclic (-)-Ambiguine P Using Sequential Indole Functionalizations.

Authors:  Rebecca E Johnson; Hwisoo Ree; Marco Hartmann; Laura Lang; Shota Sawano; Richmond Sarpong
Journal:  J Am Chem Soc       Date:  2019-02-04       Impact factor: 15.419

2.  A Unifying Synthesis Approach to the C18-, C19-, and C20-Diterpenoid Alkaloids.

Authors:  Kevin G M Kou; Svitlana Kulyk; Christopher J Marth; Jack C Lee; Nicolle A Doering; Beryl X Li; Gary M Gallego; Terry P Lebold; Richmond Sarpong
Journal:  J Am Chem Soc       Date:  2017-09-20       Impact factor: 15.419

3.  A Photoswitchable Inhibitor of the Human Serotonin Transporter.

Authors:  Bichu Cheng; Johannes Morstein; Lucy Kate Ladefoged; Jannick Bang Maesen; Birgit Schiøtt; Steffen Sinning; Dirk Trauner
Journal:  ACS Chem Neurosci       Date:  2020-04-23       Impact factor: 4.418

4.  Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid.

Authors:  Cillian Byrne; Kate M Houlihan; Prarthana Devi; Paul Jensen; Peter J Rutledge
Journal:  Molecules       Date:  2014-12-12       Impact factor: 4.411

5.  Network-analysis-guided synthesis of weisaconitine D and liljestrandinine.

Authors:  C J Marth; G M Gallego; J C Lee; T P Lebold; S Kulyk; K G M Kou; J Qin; R Lilien; R Sarpong
Journal:  Nature       Date:  2015-12-24       Impact factor: 49.962

6.  A unified strategy to reverse-prenylated indole alkaloids: total syntheses of preparaherquamide, premalbrancheamide, and (+)-VM-55599.

Authors:  Jose B Roque; Eduardo V Mercado-Marin; Sven C Richter; Danilo Pereira de Sant'Ana; Ken Mukai; Yingda Ye; Richmond Sarpong
Journal:  Chem Sci       Date:  2020-05-28       Impact factor: 9.825
  6 in total

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