OBJECTIVE: To determine the relative efficacy of peer support and pager messaging strategies versus usual care to improve medication adherence and clinical outcomes among HIV-positive outpatients initiating or switching to a new highly active antiretroviral therapy regimen. DESIGN: A 2 3 2 factorial randomized controlled trial of a 3-month intervention with computer-assisted self-interviews and blood draws administered at baseline, 3, 6, and 9 months. METHODS:HIV-positive patients at a public HIV specialty clinic in Seattle,WA (N = 224) were randomly assigned to peer support, pager messaging, both strategies, or usual care. The main outcomes were adherence according to self-report and electronic drug monitoring, CD4 count, and HIV-1 RNA viral load. RESULTS: Intent-to-treat analyses suggested the peer intervention was associated with greater self-reported adherence at immediate postintervention. However, these effects were not maintained at follow-up assessment; nor were there significant differences in biological outcomes. The pager intervention, on the other hand, was not associated with greater adherence but was associated with improved biological outcomes at postintervention that were sustained at follow-up. CONCLUSIONS: Analyses indicate the potential efficacy of peer support and pager messaging to promote antiretroviral adherence and biological outcomes, respectively. More potent strategies still are needed.
RCT Entities:
OBJECTIVE: To determine the relative efficacy of peer support and pager messaging strategies versus usual care to improve medication adherence and clinical outcomes among HIV-positive outpatients initiating or switching to a new highly active antiretroviral therapy regimen. DESIGN: A 2 3 2 factorial randomized controlled trial of a 3-month intervention with computer-assisted self-interviews and blood draws administered at baseline, 3, 6, and 9 months. METHODS: HIV-positive patients at a public HIV specialty clinic in Seattle,WA (N = 224) were randomly assigned to peer support, pager messaging, both strategies, or usual care. The main outcomes were adherence according to self-report and electronic drug monitoring, CD4 count, and HIV-1 RNA viral load. RESULTS: Intent-to-treat analyses suggested the peer intervention was associated with greater self-reported adherence at immediate postintervention. However, these effects were not maintained at follow-up assessment; nor were there significant differences in biological outcomes. The pager intervention, on the other hand, was not associated with greater adherence but was associated with improved biological outcomes at postintervention that were sustained at follow-up. CONCLUSIONS: Analyses indicate the potential efficacy of peer support and pager messaging to promote antiretroviral adherence and biological outcomes, respectively. More potent strategies still are needed.
Authors: Lynne T Harris; Keren Lehavot; David Huh; Samantha Yard; Michele P Andrasik; Peter J Dunbar; Jane M Simoni Journal: Telemed J E Health Date: 2010-11-18 Impact factor: 3.536
Authors: Nancy F Crum; Robert H Riffenburgh; Scott Wegner; Brian K Agan; Sybil A Tasker; Katherine M Spooner; Adam W Armstrong; Susan Fraser; Mark R Wallace Journal: J Acquir Immune Defic Syndr Date: 2006-02-01 Impact factor: 3.731
Authors: Robert H Remien; Michael J Stirratt; Curtis Dolezal; Joanna S Dognin; Glenn J Wagner; Alex Carballo-Dieguez; Nabila El-Bassel; Tiffany M Jung Journal: AIDS Date: 2005-05-20 Impact factor: 4.177
Authors: P T Nieuwkerk; M A Sprangers; D M Burger; R M Hoetelmans; P W Hugen; S A Danner; M E van Der Ende; M M Schneider; G Schrey; P L Meenhorst; H G Sprenger; R H Kauffmann; M Jambroes; M A Chesney; F de Wolf; J M Lange Journal: Arch Intern Med Date: 2001-09-10
Authors: Rochelle P Walensky; A David Paltiel; Elena Losina; Lauren M Mercincavage; Bruce R Schackman; Paul E Sax; Milton C Weinstein; Kenneth A Freedberg Journal: J Infect Dis Date: 2006-06-01 Impact factor: 5.226
Authors: Hernando Knobel; Jordi Alonso; José L Casado; Julio Collazos; Juan González; Isabel Ruiz; José M Kindelan; Alexia Carmona; Javier Juega; Antonio Ocampo Journal: AIDS Date: 2002-03-08 Impact factor: 4.177
Authors: Jennifer L Peterson; Lance S Rintamaki; Dale E Brashers; Daena J Goldsmith; Judith L Neidig Journal: J Assoc Nurses AIDS Care Date: 2011-11-13 Impact factor: 1.354
Authors: Lynne T Harris; Keren Lehavot; David Huh; Samantha Yard; Michele P Andrasik; Peter J Dunbar; Jane M Simoni Journal: Telemed J E Health Date: 2010-11-18 Impact factor: 3.536
Authors: Jane M Simoni; Frances M Aunon; Christopher G Kemp; Bryan A Kutner; Megan K Ramaiya; Jennifer Velloza; Joyce P Yang Journal: Lancet Infect Dis Date: 2017-03-03 Impact factor: 25.071
Authors: Marcia Vervloet; Annemiek J Linn; Julia C M van Weert; Dinny H de Bakker; Marcel L Bouvy; Liset van Dijk Journal: J Am Med Inform Assoc Date: 2012-04-25 Impact factor: 4.497
Authors: Mahnaz R Charania; Khiya J Marshall; Cynthia M Lyles; Nicole Crepaz; Linda S Kay; Linda J Koenig; Paul J Weidle; David W Purcell Journal: AIDS Behav Date: 2014-04
Authors: Hailey J Gilmore; Albert Liu; Kimberly Ann Koester; K Rivet Amico; Vanessa McMahan; Pedro Goicochea; Lorena Vargas; David Lubensky; Susan Buchbinder; Robert Grant Journal: AIDS Patient Care STDS Date: 2013-10 Impact factor: 5.078