BACKGROUND AND PURPOSE: Light-to-moderate alcohol consumption has been associated with reduced risk of total and ischemic stroke. However, data on the relationship between alcohol consumption and functional outcomes from stroke are sparse. METHODS: Prospective cohort study among 21 860 men enrolled in the Physicians' Health Study who provided information on alcohol consumption at baseline and had no prior history of stroke or transient ischemic attack (TIA). Alcohol consumption was divided into 5 categories: <1 drink/wk, 1 drink/wk, 2 to 4 drinks/wk, 5 to 6 drinks/wk, and >/=1 drink/d. Possible functional outcomes included TIA, modified Rankin Scale (mRS)=0 to 1, mRS=2 to 3, and mRS=4 to 6. We used multinomial logistic regression to evaluate the relationship between levels of alcohol consumption and functional outcomes from stroke. RESULTS: During a mean of 21.6 years of follow-up, 766 TIAs and 1393 strokes (1157 ischemic, 222 hemorrhagic, and 14 unknown type) occurred. Men who consumed 1 drink/wk had lowest associated odds for any outcome. Compared with men who did not experience a TIA or stroke and who consumed <1 drink/wk, men who consumed 1 drink/wk had odds ratio (95% CI) for total stroke of 0.85 (0.60 to 1.21) for mRS=0 to 1, 0.84 (0.64 to 1.10) for mRS=2 to 3, and 0.60 (0.37 to 0.97) for mRS=4 to 6. The odds ratio for TIA was 0.95 (0.73 to 1.23). The pattern of association did not substantially differ for ischemic and hemorrhagic stroke. Higher alcohol consumption showed no association with functional outcome after stroke. CONCLUSIONS: Our data do not show strong associations between alcohol consumption and functional outcome after stroke. Modest beneficial associations exist with low alcohol consumption.
RCT Entities:
BACKGROUND AND PURPOSE: Light-to-moderate alcohol consumption has been associated with reduced risk of total and ischemic stroke. However, data on the relationship between alcohol consumption and functional outcomes from stroke are sparse. METHODS: Prospective cohort study among 21 860 men enrolled in the Physicians' Health Study who provided information on alcohol consumption at baseline and had no prior history of stroke or transient ischemic attack (TIA). Alcohol consumption was divided into 5 categories: <1 drink/wk, 1 drink/wk, 2 to 4 drinks/wk, 5 to 6 drinks/wk, and >/=1 drink/d. Possible functional outcomes included TIA, modified Rankin Scale (mRS)=0 to 1, mRS=2 to 3, and mRS=4 to 6. We used multinomial logistic regression to evaluate the relationship between levels of alcohol consumption and functional outcomes from stroke. RESULTS: During a mean of 21.6 years of follow-up, 766 TIAs and 1393 strokes (1157 ischemic, 222 hemorrhagic, and 14 unknown type) occurred. Men who consumed 1 drink/wk had lowest associated odds for any outcome. Compared with men who did not experience a TIA or stroke and who consumed <1 drink/wk, men who consumed 1 drink/wk had odds ratio (95% CI) for total stroke of 0.85 (0.60 to 1.21) for mRS=0 to 1, 0.84 (0.64 to 1.10) for mRS=2 to 3, and 0.60 (0.37 to 0.97) for mRS=4 to 6. The odds ratio for TIA was 0.95 (0.73 to 1.23). The pattern of association did not substantially differ for ischemic and hemorrhagic stroke. Higher alcohol consumption showed no association with functional outcome after stroke. CONCLUSIONS: Our data do not show strong associations between alcohol consumption and functional outcome after stroke. Modest beneficial associations exist with low alcohol consumption.
Authors: Howard D Sesso; Julie E Buring; William G Christen; Tobias Kurth; Charlene Belanger; Jean MacFadyen; Vadim Bubes; JoAnn E Manson; Robert J Glynn; J Michael Gaziano Journal: JAMA Date: 2008-11-09 Impact factor: 56.272
Authors: Kristi Reynolds; Brian Lewis; John David L Nolen; Gregory L Kinney; Bhavani Sathya; Jiang He; Brian L Lewis Journal: JAMA Date: 2003-02-05 Impact factor: 56.272
Authors: Jonathan W Sturm; Geoffrey A Donnan; Helen M Dewey; Richard A L Macdonell; Amanda K Gilligan; Amanda G Thrift Journal: Stroke Date: 2004-02-12 Impact factor: 7.914
Authors: Ashfaq Shuaib; Kennedy R Lees; Patrick Lyden; James Grotta; Antonio Davalos; Stephen M Davis; Hans-Christoph Diener; Tim Ashwood; Warren W Wasiewski; Ugochi Emeribe Journal: N Engl J Med Date: 2007-08-09 Impact factor: 91.245
Authors: J Michael Gaziano; Robert J Glynn; William G Christen; Tobias Kurth; Charlene Belanger; Jean MacFadyen; Vadim Bubes; JoAnn E Manson; Howard D Sesso; Julie E Buring Journal: JAMA Date: 2008-12-09 Impact factor: 56.272
Authors: Christian Weimar; Tobias Kurth; Klaus Kraywinkel; Markus Wagner; Otto Busse; Roman Ludwig Haberl; Hans-Christoph Diener Journal: Stroke Date: 2002-08 Impact factor: 7.914
Authors: Katherine M Keyes; Esteban Calvo; Katherine A Ornstein; Caroline Rutherford; Matthew P Fox; Ursula M Staudinger; Linda P Fried Journal: Alcohol Clin Exp Res Date: 2019-07-05 Impact factor: 3.455