BACKGROUND AND PURPOSE: The first genomewide association study of ischemic stroke in whites has identified multiple susceptibility loci. We confirmed this study by examining associations with ischemic stroke in a Chinese Han population. METHODS: Twenty-five common variants were genotyped in a relatively large sample size including 1123 subjects with ischemic stroke cases (thrombosis stroke=716, lacunar infarction=407) and 557 normal control subjects. The association analyses were performed at both single nucleotide polymorphism and haplotype levels. False discovery rate q value method was applied for multiple testing corrections. RESULTS: rs11052413, a intergenic single nucleotide polymorphism, was most significantly associated with ischemic stroke independent of traditional cardiovascular risk factors in additive (OR=1.51, 95% CI=1.19 to 1.92, P=7.4 x 10(-4), q=0.018) and dominant models (OR=1.59, 95% CI=1.20 to 2.08, P=9.2 x 10(-4), q=0.023). In addition, both ZNF650 rs10204475 and intergenic single nucleotide polymorphism rs10486776 were associated with ischemic stroke as well as independent of traditional cardiovascular risk factors in dominant models (OR=1.47, 95% CI=1.12 to 1.96, P=0.005, q=0.040 and OR=1.53, 95% CI=1.15 to 2.02, P=0.003, q=0.036, respectively). No significant results were found in stroke subtype analysis after multiple corrections. CONCLUSIONS: Our study confirmed previously reported associations between ischemic stroke and rs11052413, rs10486776, and ZNF 650 rs10204475 in a Chinese Han population. The mechanism whereby the genetic variants exert their effects on ischemic stroke remains to be further elucidated.
BACKGROUND AND PURPOSE: The first genomewide association study of ischemic stroke in whites has identified multiple susceptibility loci. We confirmed this study by examining associations with ischemic stroke in a Chinese Han population. METHODS: Twenty-five common variants were genotyped in a relatively large sample size including 1123 subjects with ischemic stroke cases (thrombosis stroke=716, lacunar infarction=407) and 557 normal control subjects. The association analyses were performed at both single nucleotide polymorphism and haplotype levels. False discovery rate q value method was applied for multiple testing corrections. RESULTS:rs11052413, a intergenic single nucleotide polymorphism, was most significantly associated with ischemic stroke independent of traditional cardiovascular risk factors in additive (OR=1.51, 95% CI=1.19 to 1.92, P=7.4 x 10(-4), q=0.018) and dominant models (OR=1.59, 95% CI=1.20 to 2.08, P=9.2 x 10(-4), q=0.023). In addition, both ZNF650rs10204475 and intergenic single nucleotide polymorphism rs10486776 were associated with ischemic stroke as well as independent of traditional cardiovascular risk factors in dominant models (OR=1.47, 95% CI=1.12 to 1.96, P=0.005, q=0.040 and OR=1.53, 95% CI=1.15 to 2.02, P=0.003, q=0.036, respectively). No significant results were found in stroke subtype analysis after multiple corrections. CONCLUSIONS: Our study confirmed previously reported associations between ischemic stroke and rs11052413, rs10486776, and ZNF 650 rs10204475 in a Chinese Han population. The mechanism whereby the genetic variants exert their effects on ischemic stroke remains to be further elucidated.
Authors: Tiago Krug; João Paulo Gabriel; Ricardo Taipa; Benedita V Fonseca; Sophie Domingues-Montanari; Israel Fernandez-Cadenas; Helena Manso; Liliana O Gouveia; João Sobral; Isabel Albergaria; Gisela Gaspar; Jordi Jiménez-Conde; Raquel Rabionet; José M Ferro; Joan Montaner; Astrid M Vicente; Mário Rui Silva; Ilda Matos; Gabriela Lopes; Sofia A Oliveira Journal: J Cereb Blood Flow Metab Date: 2012-03-28 Impact factor: 6.200
Authors: Tatiana Foroud; Dongbing Lai; Daniel Koller; Femke Van't Hof; Mitja I Kurki; Craig S Anderson; Robert D Brown; Edward Sander Connolly; Johan G Eriksson; Matthew Flaherty; Myriam Fornage; Mikael von Und Zu Fraunberg; Emília I Gaál; Aki Laakso; Juha Hernesniemi; John Huston; Juha E Jääskeläinen; Lambertus A Kiemeney; Riku Kivisaari; Dawn Kleindorfer; Nerissa Ko; Hanna Lehto; Jason Mackey; Irene Meissner; Charles J Moomaw; Thomas H Mosley; Marek Moskala; Mika Niemelä; Aarno Palotie; Joanna Pera; Gabriel Rinkel; Stephan Ripke; Guy Rouleau; Ynte Ruigrok; Laura Sauerbeck; Agnieszka Słowik; Sita H Vermeulen; Daniel Woo; Bradford B Worrall; Joseph Broderick Journal: Stroke Date: 2014-09-25 Impact factor: 7.914
Authors: R T Yang; M Y Wang; C N Li; H Yu; X W Wang; J H Wu; S Y Wang; J T Wang; D F Chen; T Wu; Y H Hu Journal: Beijing Da Xue Xue Bao Yi Xue Ban Date: 2022-06-18