UNLABELLED: (R)-[(11)C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[(11)C]PK11195 studies in traumatic brain injury (TBI), where blood-brain barrier disruptions are likely. METHODS: Dynamic (R)-[(11)C]PK11195 scans were acquired at 3 time points after TBI. Plasma input-derived binding potential (BP(ND)(PI)), volume of distribution (V(T)) and K(1)/k(2), and simplified reference tissue model-derived binding potential (BP(ND)(SRTM)) were obtained. Simulations were performed to assess the effect of varying K(1)/k(2). RESULTS: Early after TBI, an increase in V(T), but not in BP(ND)(PI), was found. Early K(1)/k(2) correlated with V(T) and BP(ND)(SRTM) but not with BP(ND)(PI). One and 6 mo after TBI, BP(ND)(SRTM) correlated with BP(ND)(PI). CONCLUSION: Early after TBI, (R)-[(11)C]PK11195 studies should be analyzed using plasma input models.
UNLABELLED: (R)-[(11)C]PK11195 is a tracer for activated microglia. The purpose of this study was to assess the validity of the simplified reference tissue model for analyzing (R)-[(11)C]PK11195 studies in traumatic brain injury (TBI), where blood-brain barrier disruptions are likely. METHODS: Dynamic (R)-[(11)C]PK11195 scans were acquired at 3 time points after TBI. Plasma input-derived binding potential (BP(ND)(PI)), volume of distribution (V(T)) and K(1)/k(2), and simplified reference tissue model-derived binding potential (BP(ND)(SRTM)) were obtained. Simulations were performed to assess the effect of varying K(1)/k(2). RESULTS: Early after TBI, an increase in V(T), but not in BP(ND)(PI), was found. Early K(1)/k(2) correlated with V(T) and BP(ND)(SRTM) but not with BP(ND)(PI). One and 6 mo after TBI, BP(ND)(SRTM) correlated with BP(ND)(PI). CONCLUSION: Early after TBI, (R)-[(11)C]PK11195 studies should be analyzed using plasma input models.
Authors: Anna Rieckmann; Trey Hedden; Alayna P Younger; Reisa A Sperling; Keith A Johnson; Randy L Buckner Journal: Hum Brain Mapp Date: 2015-11-06 Impact factor: 5.038
Authors: Elisabeth A Wilde; Sylvain Bouix; David F Tate; Alexander P Lin; Mary R Newsome; Brian A Taylor; James R Stone; James Montier; Samuel E Gandy; Brian Biekman; Martha E Shenton; Gerald York Journal: Brain Imaging Behav Date: 2015-09 Impact factor: 3.978
Authors: Aaron P Schultz; Reina W Kloet; Hamid R Sohrabi; Louise van der Weerd; Sanneke van Rooden; Marieke J H Wermer; Laure Grand Moursel; Maqsood Yaqub; Bart N M van Berckel; Pratishtha Chatterjee; Samantha L Gardener; Kevin Taddei; Anne M Fagan; Tammie L Benzinger; John C Morris; Reisa Sperling; Keith Johnson; Randall J Bateman; M Edip Gurol; Mark A van Buchem; Ralph Martins; Jasmeer P Chhatwal; Steven M Greenberg Journal: Ann Neurol Date: 2019-08-12 Impact factor: 10.422
Authors: Niina Vuokila; Katarzyna Lukasiuk; Anna Maria Bot; Erwin A van Vliet; Eleonora Aronica; Asla Pitkänen; Noora Puhakka Journal: Cell Mol Life Sci Date: 2018-08-28 Impact factor: 9.261
Authors: Hervé Boutin; Katie Murray; Jesus Pradillo; Renaud Maroy; Alison Smigova; Alexander Gerhard; Paul A Jones; William Trigg Journal: Eur J Nucl Med Mol Imaging Date: 2014-10-29 Impact factor: 9.236
Authors: Hedy Folkersma; Jessica C Foster Dingley; Bart N M van Berckel; Annemieke Rozemuller; Ronald Boellaard; Marc C Huisman; Adriaan A Lammertsma; W Peter Vandertop; Carla F M Molthoff Journal: J Neuroinflammation Date: 2011-06-14 Impact factor: 8.322
Authors: Thomas Sc Ng; Alexander P Lin; Inga K Koerte; Ofer Pasternak; Huijun Liao; Sai Merugumala; Sylvain Bouix; Martha E Shenton Journal: Alzheimers Res Ther Date: 2014-02-24 Impact factor: 6.982