Literature DB >> 19910192

Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates.

Sunny Manohar1, Shabana I Khan, Diwan S Rawat.   

Abstract

A series of 4-aminoquinoline-triazine conjugates with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum. Compounds 16, 19, 28 and 35 exhibited promising antimalarial activity against both strains of P. falciparum. Cytotoxicity of these compounds was tested against three cell lines. Several compounds did not show any cytotoxicity up to a high concentration (48microM), others exhibited mild toxicities but selective index for antimalarial activity was high for most of these conjugates. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19910192     DOI： 10.1016/j.bmcl.2009.10.106

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity.

Authors:  Sunny Manohar; U Chinna Rajesh; Shabana I Khan; Babu L Tekwani; Diwan S Rawat
Journal:  ACS Med Chem Lett       Date:  2012-06-10       Impact factor: 4.345

2.  Hybridization of Fluoro-amodiaquine (FAQ) with Pyrimidines: Synthesis and Antimalarial Efficacy of FAQ-Pyrimidines.

Authors:  Mohit Tripathi; Dale Taylor; Shabana I Khan; Babu L Tekwani; Prija Ponnan; Ujjalkumar Subhash Das; Thirumurthy Velpandian; Diwan S Rawat
Journal:  ACS Med Chem Lett       Date:  2019-03-13       Impact factor: 4.345

3.  Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.

Authors:  Kamaljit Singh; Hardeep Kaur; Kelly Chibale; Jan Balzarini
Journal:  Eur J Med Chem       Date:  2013-06-10       Impact factor: 6.514

4.  Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game.

Authors:  Anamika Sharma; Ayman El-Faham; Beatriz G de la Torre; Fernando Albericio
Journal:  Front Chem       Date:  2018-11-01       Impact factor: 5.221

5.  Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity.

Authors:  Anna C C Aguiar; Erika Murce; Wilian A Cortopassi; Andre S Pimentel; Maria M F S Almeida; Daniele C S Barros; Jéssica S Guedes; Mario R Meneghetti; Antoniana U Krettli
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2018-10-13       Impact factor: 4.077

6.  Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-s-triazines.

Authors:  Prashant Gahtori; Surajit Kumar Ghosh; Brijesh Singh; Udaya Pratap Singh; Hans Raj Bhat; Archana Uppal
Journal:  Saudi Pharm J       Date:  2011-05-17       Impact factor: 4.330
  6 in total

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