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Literature DB >> 19909257

ERK5 and the regulation of endothelial cell function.

Owain Llŷr Roberts¹, Katherine Holmes, Jürgen Müller, Darren A E Cross, Michael J Cross.

Abstract

ERK5 (extracellular-signal-regulated kinase 5), also termed BMK1 [big MAPK1 (mitogen-activated protein kinase 1)], is the most recently discovered member of the MAPK family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.

Entities: Disease Gene Species

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Year: 2009 PMID： 19909257 DOI： 10.1042/BST0371254

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

30 in total

1. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells.

Authors: Debanjan Chakroborty; Chandrani Sarkar; Hongmei Yu; Jiang Wang; Zhongfa Liu; Partha Sarathi Dasgupta; Sujit Basu
Journal: Proc Natl Acad Sci U S A Date: 2011-12-05 Impact factor: 11.205

2. Extracellular-regulated-kinase 5-mediated renal protection against ischemia-reperfusion injury.

Authors: Tomoko Kawakami; Sang Won Park; Ryuji Kaku; Jay Yang
Journal: Biochem Biophys Res Commun Date: 2012-01-24 Impact factor: 3.575

3. Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population.

Authors: Dechang Diao; Lei Wang; Jun-Xiao Zhang; Dianke Chen; Huanliang Liu; Yisheng Wei; Jiachun Lu; Junsheng Peng; Jianping Wang
Journal: DNA Cell Biol Date: 2011-08-23 Impact factor: 3.311

4. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas.

Authors: Charlotte S Wilhelm-Benartzi; Brock C Christensen; Devin C Koestler; E Andres Houseman; Alan R Schned; Margaret R Karagas; Karl T Kelsey; Carmen J Marsit
Journal: Cancer Causes Control Date: 2011-06-10 Impact factor: 2.506

5. Dehydrocostus lactone suppresses ox-LDL-induced attachment of monocytes to endothelial cells.

Authors: Kai Wang; Aihua Zhou; Miaohua Ruan; Zengyou Jin; Jiacheng Lu; Qiu Wang; Chaosheng Lu
Journal: Am J Transl Res Date: 2019-09-15 Impact factor: 4.060

6. ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.

Authors: Kevin Wilhelmsen; Kailin R Mesa; Jennifer Lucero; Fengyun Xu; Judith Hellman
Journal: J Biol Chem Date: 2012-06-15 Impact factor: 5.157

ERK5 and the regulation of endothelial cell function.

1. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells.

2. Extracellular-regulated-kinase 5-mediated renal protection against ischemia-reperfusion injury.

3. Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population.

4. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas.

5. Dehydrocostus lactone suppresses ox-LDL-induced attachment of monocytes to endothelial cells.

6. ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.

7. Inhibition of ERK5 enhances cytarabine-induced apoptosis in acute myeloid leukemia cells.

8. CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes.

9. Role of extracellular signal-regulated kinase 5 in adipocyte signaling.

10. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.