| Literature DB >> 19908867 |
Faustine Dubar1, Guillaume Anquetin, Bruno Pradines, Daniel Dive, Jamal Khalife, Christophe Biot.
Abstract
The derivatization of the fluoroquinolone ciprofloxacin greatly increases its antimalarial activity by combining bioorganometallic chemistry and the prodrug approach. Two new achiral compounds 2 and 4 were found to be 10- to 100-fold more active than ciprofloxacin against Plasmodium falciparum chloroquine-susceptible and chloroquine-resistant strains. These achiral derivatives killed parasites more rapidly than did ciprofloxacin. Compounds 2 and 4 were revealed to be promising leads, creating a new family of antimalarial agents.Entities:
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Year: 2009 PMID： 19908867 DOI： 10.1021/jm901357n
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446