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Literature DB >> 1990832

Why are autism and the fragile-X syndrome associated? Conceptual and methodological issues.

I L Cohen¹, V Sudhalter, A Pfadt, E C Jenkins, W T Brown, P M Vietze.

Abstract

Investigations of the association between autism and the fragile-X syndrome have yielded conflicting results with some studies indicating a strong correlation and others indicating no relation between the disorders. In this paper, we review the relevant research on this controversy and discuss the conceptual and methodological problems involved in such an inquiry. We conclude that autism and fragile X are associated and that this relation will prove fruitful in understanding the role of the X chromosome in a variety of behavior disorders and in unraveling various theoretical accounts on the etiology of autism.

Entities: Disease

Mesh：

Year: 1991 PMID： 1990832 PMCID： PMC1683028

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

26 in total

1. Fragile X in a survey of 75 autistic males.

Authors: M S Watson; J F Leckman; B Annex; W R Breg; D Boles; F R Volkmar; D J Cohen; C Carter
Journal: N Engl J Med Date: 1984-05-31 Impact factor: 91.245

2. Autism is associated with the fragile-X syndrome.

Authors: W T Brown; E C Jenkins; E Friedman; J Brooks; K Wisniewski; S Raguthu; J French
Journal: J Autism Dev Disord Date: 1982-09

3. Infantile autism associated with the fragile-X syndrome.

Authors: D L Meryash; L S Szymanski; P S Gerald
Journal: J Autism Dev Disord Date: 1982-09

4. The biological significance of gaze aversion with particular reference to the syndrome of infantile autism.

Authors: C Hutt; C Ounsted
Journal: Behav Sci Date: 1966-09

5. Parent-child dyadic gaze patterns in fragile X males and in non-fragile X males with autistic disorder.

Authors: I L Cohen; P M Vietze; V Sudhalter; E C Jenkins; W T Brown
Journal: J Child Psychol Psychiatry Date: 1989-11 Impact factor: 8.982

6. Learning disabilities and attentional problems in boys with the fragile X syndrome.

Authors: R Hagerman; M Kemper; M Hudson
Journal: Am J Dis Child Date: 1985-07

7. Frequency of the fragile X syndrome in infantile autism. A Swedish multicenter study.

Authors: H K Blomquist; M Bohman; S O Edvinsson; C Gillberg; K H Gustavson; G Holmgren; J Wahlström
Journal: Clin Genet Date: 1985-02 Impact factor: 4.438

8. The fragile X syndrome II: preliminary data on growth and development in males.

Authors: M W Partington
Journal: Am J Med Genet Date: 1984-01

9. Identical triplets with infantile autism and the fragile-X syndrome.

Authors: C Gillberg
Journal: Br J Psychiatry Date: 1983-09 Impact factor: 9.319

10. Association of fragile X syndrome with autism.

Authors: P E Goldfine; P M McPherson; G A Heath; V A Hardesty; L J Beauregard; B Gordon
Journal: Am J Psychiatry Date: 1985-01 Impact factor: 18.112

27 in total

Review 1. The screening and diagnosis of autistic spectrum disorders.

Authors: P A Filipek; P J Accardo; G T Baranek; E H Cook; G Dawson; B Gordon; J S Gravel; C P Johnson; R J Kallen; S E Levy; N J Minshew; S Ozonoff; B M Prizant; I Rapin; S J Rogers; W L Stone; S Teplin; R F Tuchman; F R Volkmar
Journal: J Autism Dev Disord Date: 1999-12

Why are autism and the fragile-X syndrome associated? Conceptual and methodological issues.

1. Fragile X in a survey of 75 autistic males.

2. Autism is associated with the fragile-X syndrome.

3. Infantile autism associated with the fragile-X syndrome.

4. The biological significance of gaze aversion with particular reference to the syndrome of infantile autism.

5. Parent-child dyadic gaze patterns in fragile X males and in non-fragile X males with autistic disorder.

6. Learning disabilities and attentional problems in boys with the fragile X syndrome.

7. Frequency of the fragile X syndrome in infantile autism. A Swedish multicenter study.

8. The fragile X syndrome II: preliminary data on growth and development in males.

9. Identical triplets with infantile autism and the fragile-X syndrome.

10. Association of fragile X syndrome with autism.

Review 1. The screening and diagnosis of autistic spectrum disorders.

2. Emotion recognition and visual-scan paths in Fragile X syndrome.

3. Brief report: the association between autism and fragile X syndrome: a case report.

4. Autistic behavior in young boys with fragile X syndrome.

Review 5. Etiology of infantile autism: a review of recent advances in genetic and neurobiological research.

6. Video analysis of sensory-motor features in infants with fragile X syndrome at 9-12 months of age.

7. Expressive language in male adolescents with fragile X syndrome with and without comorbid autism.

Review 8. Neuropsychiatric symptoms of fragile X syndrome: pathophysiology and pharmacotherapy.

9. Complex segregation analysis of autism.

10. Autism and tuberous sclerosis.