PURPOSE: To assess the effects of gender and hormone status on the severity and progression of keratoconus in patients enrolled in the Collaborative Longitudinal Evaluation of Keratoconus Study. METHODS: The severity and progression of keratoconus in both men (M) and women were evaluated over a 4-year period that encompassed menopausal transition for hormone-active women (HA) and hormone-inactive women (HI). Four outcome measures were selected as indicators of the severity of keratoconus: high-contrast best-corrected visual acuity, low-contrast best-corrected visual acuity, the steep keratometric measurement, and corneal scarring (yes/no). RESULTS: There were no statistically significant differences among the 3 groups (M, HA, and HI) in race, history of atopic disease, family history of keratoconus, or rigid contact lens wear in the right and left eyes. At baseline, there were no significant differences among the 3 groups in high-contrast best-corrected visual acuity, low-contrast best-corrected visual acuity, or steep keratometric reading. Progression of keratoconus, as assessed by changes in these 3 continuous variables, was equal for the 3 groups. M had more corneal scarring than did HA or HI; however, there was no progression of scarring for any of the groups. CONCLUSION: Keratoconus progressed in both men and women, aged 48-59 years; however, there were no differences among the groups in progression.
PURPOSE: To assess the effects of gender and hormone status on the severity and progression of keratoconus in patients enrolled in the Collaborative Longitudinal Evaluation of Keratoconus Study. METHODS: The severity and progression of keratoconus in both men (M) and women were evaluated over a 4-year period that encompassed menopausal transition for hormone-active women (HA) and hormone-inactive women (HI). Four outcome measures were selected as indicators of the severity of keratoconus: high-contrast best-corrected visual acuity, low-contrast best-corrected visual acuity, the steep keratometric measurement, and corneal scarring (yes/no). RESULTS: There were no statistically significant differences among the 3 groups (M, HA, and HI) in race, history of atopic disease, family history of keratoconus, or rigid contact lens wear in the right and left eyes. At baseline, there were no significant differences among the 3 groups in high-contrast best-corrected visual acuity, low-contrast best-corrected visual acuity, or steep keratometric reading. Progression of keratoconus, as assessed by changes in these 3 continuous variables, was equal for the 3 groups. M had more corneal scarring than did HA or HI; however, there was no progression of scarring for any of the groups. CONCLUSION: Keratoconus progressed in both men and women, aged 48-59 years; however, there were no differences among the groups in progression.
Authors: Marta Czugala; Justyna A Karolak; Dorota M Nowak; Piotr Polakowski; Jose Pitarque; Andrea Molinari; Malgorzata Rydzanicz; Bassem A Bejjani; Beatrice Y J T Yue; Jacek P Szaflik; Marzena Gajecka Journal: Eur J Hum Genet Date: 2011-11-02 Impact factor: 4.246
Authors: Tina B McKay; Jesper Hjortdal; Henrik Sejersen; John M Asara; Jennifer Wu; Dimitrios Karamichos Journal: Sci Rep Date: 2016-05-09 Impact factor: 4.379
Authors: Ewelina Synowiec; Katarzyna A Wójcik; Anna Czubatka; Piotr Polakowski; Justyna Izdebska; Jerzy Szaflik; Janusz Błasiak; Jacek P Szaflik Journal: Arch Med Sci Date: 2015-10-12 Impact factor: 3.318
Authors: Ewelina Synowiec; Katarzyna A Wojcik; Justyna Izdebska; Ewelina Binczyk; Janusz Blasiak; Jerzy Szaflik; Jacek P Szaflik Journal: Dis Markers Date: 2013-09-25 Impact factor: 3.434