PURPOSE: To investigate the relative impacts of age and cigarette smoking on cutaneous blood flow and flow motion. EXPERIMENTAL DESIGN: Skin blood flux was measured before and during the hyperaemic response to thermal warming of the skin to 43 degrees C using laser Doppler fluximetry (LDF) in 28 habitual smokers (5.4 [11.4] (median [IQR]) pack years; pack years = packs/day x duration of smoking habit), aged between 18 and 63 years and their age, sex and body mass index. Flow motion was assessed using Fourier analysis of the LDF signal. RESULTS: Mean and total hyperaemic (area under the flux curve, AUC(10)) response during warming were reduced in smokers compared with their non-smoking controls (P<0.05). Attenuation of the response to warming in smokers was associated with a reduction in relative spectral power around 0.01 Hz, reflecting a reduced endothelial/metabolic activity (P<0.04). In regression modelling with AUC(10) as the outcome, and smoking (yes/no), age, sex and BMI, as explanatory variables, age (P<0.0001) and smoking (P=0.018) were independently associated with the hyperaemic response and together accounted for 31% of the variance in AUC(10). CONCLUSIONS: Age and smoking are associated with approximately one-third of the variance in the endothelium-associated microvascular vasomotor activity in habitual smokers.
PURPOSE: To investigate the relative impacts of age and cigarette smoking on cutaneous blood flow and flow motion. EXPERIMENTAL DESIGN: Skin blood flux was measured before and during the hyperaemic response to thermal warming of the skin to 43 degrees C using laser Doppler fluximetry (LDF) in 28 habitual smokers (5.4 [11.4] (median [IQR]) pack years; pack years = packs/day x duration of smoking habit), aged between 18 and 63 years and their age, sex and body mass index. Flow motion was assessed using Fourier analysis of the LDF signal. RESULTS: Mean and total hyperaemic (area under the flux curve, AUC(10)) response during warming were reduced in smokers compared with their non-smoking controls (P<0.05). Attenuation of the response to warming in smokers was associated with a reduction in relative spectral power around 0.01 Hz, reflecting a reduced endothelial/metabolic activity (P<0.04). In regression modelling with AUC(10) as the outcome, and smoking (yes/no), age, sex and BMI, as explanatory variables, age (P<0.0001) and smoking (P=0.018) were independently associated with the hyperaemic response and together accounted for 31% of the variance in AUC(10). CONCLUSIONS: Age and smoking are associated with approximately one-third of the variance in the endothelium-associated microvascular vasomotor activity in habitual smokers.
Authors: Simo Näyhä; Hannu Rintamäki; Gavin Donaldson; Juhani Hassi; Pekka Jousilahti; Tiina Laatikainen; Jouni J K Jaakkola; Tiina M Ikäheimo Journal: Int J Biometeorol Date: 2016-09-22 Impact factor: 3.787
Authors: Giuseppe A Scardina; Massimiliano Messina; Dario Melilli; Enzo Cumbo; Francesco Carini; Giovanni Tomasello; Pietro Messina Journal: Med Sci Monit Date: 2019-01-30
Authors: Kalle Kainiemi; Antti Malmivaara; Sari Sillman-Tetri; Mervi Lasander; Minna Heinonen; Tellervo Korhonen; Juhani Sand; Tiina Laatikainen; Antti Kyrö Journal: Tob Prev Cessat Date: 2022-08-29