| Literature DB >> 19904996 |
Hongjie Zhang1, Katharina Rothwangl, Andrew D Mesecar, Ali Sabahi, Lijun Rong, Harry H S Fong.
Abstract
Phytochemical study of the aqueous extract of the flowering tops of Lamium album led to identification of the antiviral iridoid isomers lamiridosins A and B (1, 2). These compounds were found to significantly inhibit hepatitis C virus entry (IC(50) 2.31 muM) in vitro. Studies of 14 iridoid analogues showed that, while the parent iridoid glucosides demonstrated no anti-HCV entry activity, the aglycones of shanzhiside methyl ester (4), loganin (5), loganic acid (6), geniposide (10), verbenalin (12), eurostoside (15), and picroside II (17) exhibited significant anti-HCV entry and anti-infectivity activities.Entities:
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Year: 2009 PMID： 19904996 DOI： 10.1021/np900549e
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050