Literature DB >> 19904542

Perspectives on overactive bladder in the elderly population.

Masaki Yoshida1.   

Abstract

INTRODUCTION: Overactive bladder (OAB) represents a disruption in the storage function of the lower urinary tract. This bothersome condition occurs more commonly in the elderly. Since population forecasts predict a worldwide increase in the proportion of people aged over 65 years, it is reasonable to expect that the healthcare burden associated with OAB will also increase. The pathophysiology of OAB in the elderly is thought to be multifactorial, with an abnormality occurring in the nervous supply and/or the structure/function of the urothelium or bladder smooth muscle, leading to bladder hypersensitivity, abnormalities in bladder sensation (urgency) and involuntary detrusor contraction.
METHODS: A review of some of the key aspects relating to management of this growing population was undertaken.
RESULTS: The potential for an elderly patient to present with a number of concomitant conditions means that careful characterization of their overall status is required before deciding on the most appropriate management option for their urinary tract pathology. Lifestyle interventions and pharmacological agents have shown success in treating OAB in the elderly, but as this patient group often has many concomitant conditions they are more likely to be seen by a non-urology specialist.
CONCLUSIONS: It is therefore important to raise awareness of the condition and an appreciation of its impact among healthcare professionals to ensure the most appropriate care.

Entities:  

Mesh:

Year:  2009        PMID: 19904542     DOI: 10.1007/s00345-009-0491-0

Source DB:  PubMed          Journal:  World J Urol        ISSN: 0724-4983            Impact factor:   4.226


  70 in total

Review 1.  The basis for drug treatment of the overactive bladder.

Authors:  K E Andersson; C Chapple; A Wein
Journal:  World J Urol       Date:  2001-11       Impact factor: 4.226

Review 2.  The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society.

Authors:  Paul Abrams; Linda Cardozo; Magnus Fall; Derek Griffiths; Peter Rosier; Ulf Ulmsten; Philip Van Kerrebroeck; Arne Victor; Alan Wein
Journal:  Urology       Date:  2003-01       Impact factor: 2.649

3.  Regulation of bladder muscarinic receptor subtypes by experimental pathologies.

Authors:  M R Ruggieri; A S Braverman
Journal:  Auton Autacoid Pharmacol       Date:  2006-07

4.  Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles.

Authors:  M Yoshida; Y Homma; A Inadome; M Yono; H Seshita; Y Miyamoto; S Murakami; K Kawabe; S Ueda
Journal:  Exp Gerontol       Date:  2001-01       Impact factor: 4.032

5.  Medically recognized urinary incontinence and risks of hospitalization, nursing home admission and mortality.

Authors:  D H Thom; M N Haan; S K Van Den Eeden
Journal:  Age Ageing       Date:  1997-09       Impact factor: 10.668

6.  Using caveolin-1 knockout mouse to study impaired detrusor contractility and disrupted muscarinic activity in the aging bladder.

Authors:  H Henry Lai; Timothy B Boone; Timothy C Thompson; Christopher P Smith; George T Somogyi
Journal:  Urology       Date:  2007-02       Impact factor: 2.649

7.  Cholinergic and purinergic responses in isolated human detrusor in relation to age.

Authors:  Melinda Wuest; Kathrin Morgenstern; Eva-Maria Graf; Manfred Braeter; Oliver W Hakenberg; Manfred P Wirth; Ursula Ravens
Journal:  J Urol       Date:  2005-06       Impact factor: 7.450

8.  Increased adrenergic contractility and decreased mRNA expression of NOS III in aging rat urinary bladders.

Authors:  P Lluel; S Palea; P Ribière; M Barras; L Teillet; B Corman
Journal:  Fundam Clin Pharmacol       Date:  2003-10       Impact factor: 2.748

9.  Age-related changes in sensitivity of rat urinary bladder to autonomic agents.

Authors:  M G Kolta; L J Wallace; M C Gerald
Journal:  Mech Ageing Dev       Date:  1984-10-15       Impact factor: 5.432

10.  Evidence for purinergic neurotransmission in the urinary bladder of pithed rats.

Authors:  S S Hegde; D A Mandel; M R Wilford; S Briaud; A P Ford; R M Eglen
Journal:  Eur J Pharmacol       Date:  1998-05-15       Impact factor: 4.432

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  5 in total

Review 1.  Translational Research and Functional Changes in Voiding Function in Older Adults.

Authors:  Florenta Aura Kullmann; Lori Ann Birder; Karl-Erik Andersson
Journal:  Clin Geriatr Med       Date:  2015-07-23       Impact factor: 3.076

2.  Association of inflammaging (inflammation + aging) with higher prevalence of OAB in elderly population.

Authors:  Pradeep Tyagi; Vikas Tyagi; Xianggui Qu; Hsin-Tzu Lin; Hann-Chorng Kuo; Yao-Chi Chuang; Michael Chancellor
Journal:  Int Urol Nephrol       Date:  2013-12-10       Impact factor: 2.370

Review 3.  Management of OAB in those over age 65.

Authors:  Ricardo Natalin; Fabio Lorenzetti; Miriam Dambros
Journal:  Curr Urol Rep       Date:  2013-10       Impact factor: 3.092

4.  A Review of Aging and the Lower Urinary Tract: The Future of Urology.

Authors:  Hisae Nishii
Journal:  Int Neurourol J       Date:  2021-12-31       Impact factor: 2.835

5.  Age-related changes in murine bladder structure and sensory innervation: a multiphoton microscopy quantitative analysis.

Authors:  Anna Schueth; Bart Spronck; Marc A M J van Zandvoort; Gommert A van Koeveringe
Journal:  Age (Dordr)       Date:  2016-01-29
  5 in total

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