Literature DB >> 19904487

Interferon-gamma release assay in the ascites: Early hint for diagnosis of abdominal tuberculosis.

R Lorenz1, P Würl, G Haerter, G Cammerer, T Barth, S Hausladen, S Stenger, P Kern.   

Abstract

We report on a 20-year-old woman with abdominal tuberculosis.Standard microbiological examination of ascites showed no acid-fast bacilli (AFB), and analysis for the Mycobacterium tuberculosis (MTB)-complex DNA by PCR was negative. However,the interferon-gamma release assay (IGRA) of the ascites was positive after specific stimulation with mycobacterial antigens(ESAT-6/CFP-10/TB7.7[p4]), indicating an infection with MTB.The diagnosis of tuberculosis was later confirmed by histology, MTB culture, and PCR analysis of MTB-complex DNA in tissue samples taken during laparoscopy. Thus, the IGRA of ascites may guide the decision to start active treatment for tuberculosis.

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Year:  2009        PMID： 19904487     DOI： 10.1007/s15010-009-9469-5

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


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  3 in total

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  3 in total

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