Literature DB >> 19904412

Towards an electrowetting-based digital microfluidic platform for magnetic immunoassays.

Vincent Schaller1, Anke Sanz-Velasco, Alexey Kalabukhov, Justin F Schneiderman, Fredrik Oisjöen, Aldo Jesorka, Andrea Prieto Astalan, Anatol Krozer, Cristina Rusu, Peter Enoksson, Dag Winkler.   

Abstract

We demonstrate ElectroWetting-On-Dielectric (EWOD) transport and SQUID gradiometer detection of magnetic nanoparticles (MNPs) suspended in a 2 microl de-ionized water droplet. This proof-of-concept methodology constitutes the first development step towards a highly sensitive magnetic immunoassay platform with SQUID readout and droplet-based sample handling. Magnetic AC-susceptibility measurements were performed on MNPs with a hydrodynamic diameter of 100 nm using a high-Tc dc Superconducting Quantum Interference Device (SQUID) gradiometer as detector. We observed that the signal amplitude per unit volume is 2.5 times higher for a 2 microl sample droplet compared to a 30 microl sample volume.

Entities:  

Mesh：

Year:  2009        PMID： 19904412     DOI： 10.1039/b912646e

Source DB:  PubMed          Journal:  Lab Chip        ISSN： 1473-0189            Impact factor:   6.799


  6 in total

Review 1.  Magnetic Nanoparticles in Cancer Therapy and Diagnosis.

Authors:  Ali Farzin; Seyed Alireza Etesami; Jacob Quint; Adnan Memic; Ali Tamayol
Journal:  Adv Healthc Mater       Date:  2020-03-20       Impact factor: 9.933

2.  Magnetic nanoparticles for biomedical NMR-based diagnostics.

Authors:  Huilin Shao; Tae-Jong Yoon; Monty Liong; Ralph Weissleder; Hakho Lee
Journal:  Beilstein J Nanotechnol       Date:  2010-12-16       Impact factor: 3.649

3.  Magnetic Nanoparticles and microNMR for Diagnostic Applications.

Authors:  Huilin Shao; Changwook Min; David Issadore; Monty Liong; Tae-Jong Yoon; Ralph Weissleder; Hakho Lee
Journal:  Theranostics       Date:  2012-01-01       Impact factor: 11.556

4.  Fabrication of a Malaria-Ab ELISA Bioassay Platform with Utilization of Syringe-Based and 3D Printed Assay Automation.

Authors:  Christopher Lim; Yangchung Lee; Lawrence Kulinsky
Journal:  Micromachines (Basel)       Date:  2018-10-02       Impact factor: 2.891

5.  Volume-amplified magnetic bioassay integrated with microfluidic sample handling and high-Tc SQUID magnetic readout.

Authors:  Sobhan Sepehri; Emil Eriksson; Alexei Kalaboukhov; Teresa Zardán Gómez de la Torre; Kiryl Kustanovich; Aldo Jesorka; Justin F Schneiderman; Jakob Blomgren; Christer Johansson; Maria Strømme; Dag Winkler
Journal:  APL Bioeng       Date:  2017-12-29

6.  Droplet microfluidics for chip-based diagnostics.

Authors:  Karan V I S Kaler; Ravi Prakash
Journal:  Sensors (Basel)       Date:  2014-12-05       Impact factor: 3.576
  6 in total

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