Literature DB >> 1990440

Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis.

M I Cybulsky1, M A Gimbrone.   

Abstract

An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated cultured endothelium in two forms, 118 and 98 kilodaltons, the amino-terminal sequence of each being highly homologous to human VCAM-1. In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions. This lesion-localized expression suggests a potential endothelium-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis and may provide a molecular marker for early atherosclerosis.

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Year:  1991        PMID： 1990440     DOI： 10.1126/science.1990440

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  322 in total

1.  Targeting and ultrasound imaging of microbubble-based contrast agents.

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Journal:  MAGMA       Date:  1999-08       Impact factor: 2.310

Review 2.  Molecular mechanisms of estrogen actions on the vasculature.

Authors:  M P Haynes; K S Russell; J R Bender
Journal:  J Nucl Cardiol       Date:  2000 Sep-Oct       Impact factor: 5.952

3.  VCAM-1 is critical in atherosclerosis.

Authors:  K Ley; Y Huo
Journal:  J Clin Invest       Date:  2001-05       Impact factor: 14.808

Review 4.  NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?

Authors:  T Collins; M I Cybulsky
Journal:  J Clin Invest       Date:  2001-02       Impact factor: 14.808

Review 5.  Inflammation and lipid-lowering treatment.

Authors:  C M Ballantyne; Y Abe
Journal:  Curr Cardiol Rep       Date:  1999-09       Impact factor: 2.931

6.  Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout.

Authors:  Daria B Crittenden; R Aaron Lehmann; Laura Schneck; Robert T Keenan; Binita Shah; Jeffrey D Greenberg; Bruce N Cronstein; Steven P Sedlis; Michael H Pillinger
Journal:  J Rheumatol       Date:  2012-06-01       Impact factor: 4.666

7.  In vivo nanoparticle assessment of pathological endothelium predicts the development of inflow stenosis in murine arteriovenous fistula.

Authors:  Jie Cui; Chase W Kessinger; Jason R McCarthy; David E Sosnovik; Peter Libby; Ravi I Thadhani; Farouc A Jaffer
Journal:  Arterioscler Thromb Vasc Biol       Date:  2014-11-13       Impact factor: 8.311

8.  Telomere length and replicative aging in human vascular tissues.

Authors:  E Chang; C B Harley
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

9.  Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.

Authors:  K D O'Brien; M D Allen; T O McDonald; A Chait; J M Harlan; D Fishbein; J McCarty; M Ferguson; K Hudkins; C D Benjamin
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

10.  Cytokine induction of an alternatively spliced murine vascular cell adhesion molecule (VCAM) mRNA encoding a glycosylphosphatidylinositol-anchored VCAM protein.

Authors:  R W Terry; L Kwee; J F Levine; M A Labow
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205
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