Literature DB >> 19904356

A DNA-based electrochemical strategy for label-free monitoring the activity and inhibition of protein kinase.

Xiahong Xu1, Zhou Nie, Jinhua Chen, Yingchun Fu, Wang Li, Qinpeng Shen, Shouzhuo Yao.   

Abstract

A novel label-free electrochemical strategy for monitoring the activity and inhibition of protein kinase is developed, based on the linkage between the phosphorylated peptide and DNA functionalized Au nanoparticles (DNA-AuNPs) by Zr(4+) and the chronocoulometric response of [Ru(NH(3))(6)](3+) absorbed on the DNA-AuNPs.

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Year:  2009        PMID: 19904356     DOI: 10.1039/b913943e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomics.

Authors:  Emil Paleček; Jan Tkáč; Martin Bartošík; Tomáš Bertók; Veronika Ostatná; Jan Paleček
Journal:  Chem Rev       Date:  2015-02-09       Impact factor: 60.622

2.  Gold nanoparticles-based electrochemical method for the detection of protein kinase with a peptide-like inhibitor as the bioreceptor.

Authors:  Kai Sun; Yong Chang; Binbin Zhou; Xiaojin Wang; Lin Liu
Journal:  Int J Nanomedicine       Date:  2017-03-09
  2 in total

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