Literature DB >> 1990387

Degenerative aortic stenosis. One effect of the graying of America.

J H O'Keefe1, C J Lavie, R A Nishimura, W D Edwards.   

Abstract

Degenerative calcific aortic stenosis is evolving as a common geriatric problem. Once symptoms develop, it is a highly lethal disease that does not respond well to medical therapy. Aortic balloon valvuloplasty may offer palliation but is unlikely to alter the overall course of the disease. Aortic valve replacement is the therapy of choice, but high perioperative morbidity and mortality rates can be expected in the very elderly. The presence of other appreciable cardiac disorders may contribute to the occurrence of postoperative complications. Patients with asymptomatic aortic stenosis and normal left ventricular function can be treated medically and followed with serial aortic valve area determinations using Doppler echocardiography.

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Year:  1991        PMID: 1990387     DOI: 10.1080/00325481.1991.11700822

Source DB:  PubMed          Journal:  Postgrad Med        ISSN: 0032-5481            Impact factor:   3.840


  6 in total

Review 1.  Ectopic calcification: gathering hard facts about soft tissue mineralization.

Authors:  C M Giachelli
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

2.  Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification.

Authors:  Susan A Steitz; Mei Y Speer; Marc D McKee; Lucy Liaw; Manuela Almeida; Hsueh Yang; Cecilia M Giachelli
Journal:  Am J Pathol       Date:  2002-12       Impact factor: 4.307

3.  Increased cellular expression of matrix proteins that regulate mineralization is associated with calcification of native human and porcine xenograft bioprosthetic heart valves.

Authors:  S S Srivatsa; P J Harrity; P B Maercklein; L Kleppe; J Veinot; W D Edwards; C M Johnson; L A Fitzpatrick
Journal:  J Clin Invest       Date:  1997-03-01       Impact factor: 14.808

Review 4.  The emerging role of phosphate in vascular calcification.

Authors:  Cecilia M Giachelli
Journal:  Kidney Int       Date:  2009-01-14       Impact factor: 10.612

5.  No association between MGP rs1800802 polymorphism and stenosis of the coronary artery.

Authors:  Abazar Roustazadeh; Mohammad Najafi; Abdollah Amirfarhangi; Issa Nourmohammadi
Journal:  Ann Saudi Med       Date:  2013 Mar-Apr       Impact factor: 1.526

6.  Mechanisms and clinical consequences of vascular calcification.

Authors:  Dongxing Zhu; Neil C W Mackenzie; Colin Farquharson; Vicky E Macrae
Journal:  Front Endocrinol (Lausanne)       Date:  2012-08-06       Impact factor: 5.555

  6 in total

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