| Literature DB >> 19902958 |
Annapurna Pendri1, Timothy L Troyer, Michael J Sofia, Michael A Walker, B Narasimhulu Naidu, Jacques Banville, Nicholas A Meanwell, Ira Dicker, Zeyu Lin, Mark Krystal, Samuel W Gerritz.
Abstract
A novel series of HIV-1 integrase inhibitors were identified from a 100 member (4R(1) x 5R(2) x 5R(3)) library of pyrrolidinedione amides. A solid-phase route was developed which facilitates the simultaneous variation at R(1), R(2), and R(3) of the pyrrolidinedione scaffold. The resulting library samples were assayed for HIV-1 integrase activity and analyzed to determine the R(1), R(2), and R(3) reagent contributions towards the activity.Entities:
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Year: 2010 PMID： 19902958 DOI： 10.1021/cc9001026
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766