Literature DB >> 19902427

A new generation of cross-linkers for selective detection by MALDI MS.

David Paramelle1, Sonia Cantel, Christine Enjalbal, Muriel Amblard, Eric Forest, Michaël Heymann, Christophe Geourjon, Jean Martinez, Gilles Subra.   

Abstract

We designed a new cross-linker bearing a CHCA moiety. The use of the CHCA-tagged cross-linker JMV 3378 in conjunction with a neutral MALDI matrix alpha-cyano-4-hydroxycinnamic methyl ester enabled specific signal enhancement in MALDI-TOF MS of cross-link containing peptides. Discrimination between modified and non-modified peptides can be achieved by comparison of two spectra, one using CHCA and the other using the alpha-cyano-4-hydroxycinnamic methyl ester matrix. The methodology was validated using cytochrome c and apo-myoglobine as model proteins.

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Year:  2009        PMID： 19902427     DOI： 10.1002/pmic.200900562

Source DB:  PubMed          Journal:  Proteomics        ISSN： 1615-9853            Impact factor:   3.984


  6 in total

1.  Elucidating the higher-order structure of biopolymers by structural probing and mass spectrometry: MS3D.

Authors:  Daniele Fabris; Eizadora T Yu
Journal:  J Mass Spectrom       Date:  2010-08       Impact factor: 1.982

2.  Chemical cross-linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex.

Authors:  Nha-Thi Nguyen-Huynh; Grigory Sharov; Clément Potel; Pélagie Fichter; Simon Trowitzsch; Imre Berger; Valérie Lamour; Patrick Schultz; Noëlle Potier; Emmanuelle Leize-Wagner
Journal:  Protein Sci       Date:  2015-04-14       Impact factor: 6.725

3.  Iminodiacetic Acid as a Novel Metal-Binding Pharmacophore for New Delhi Metallo-β-lactamase Inhibitor Development.

Authors:  Allie Y Chen; Caitlyn A Thomas; Pei W Thomas; Kundi Yang; Zishuo Cheng; Walter Fast; Michael W Crowder; Seth M Cohen
Journal:  ChemMedChem       Date:  2020-05-07       Impact factor: 3.466

4.  Elucidating protein inter- and intramolecular interacting domains using chemical cross-linking and matrix-assisted laser desorption ionization-time of flight/time of flight mass spectrometry.

Authors:  Gwënaël Pottiez; Pawel Ciborowski
Journal:  Anal Biochem       Date:  2011-12-13       Impact factor: 3.365

5.  Towards the rational design of ionic liquid matrices for secondary ion mass spectrometry: role of the anion.

Authors:  Jennifer J Dertinger; Amy V Walker
Journal:  J Am Soc Mass Spectrom       Date:  2013-05-31       Impact factor: 3.109

6.  The beginning of a beautiful friendship: cross-linking/mass spectrometry and modelling of proteins and multi-protein complexes.

Authors:  Juri Rappsilber
Journal:  J Struct Biol       Date:  2010-10-26       Impact factor: 2.867
  6 in total

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