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Literature DB >> 19902247

Cellular immune response to Mycobacterium tuberculosis-specific antigen culture filtrate protein-10 in south India.

Madhan Kumar¹, Jagadish C Sundaramurthi, Narinder K Mehra, Gurvinder Kaur, Alamelu Raja.

Abstract

The Mycobacterium tuberculosis (M. tuberculosis)-specific culture filtrate protein-10 (CFP-10) is highly recognized by M. tuberculosis infected subjects. In the present study, the proliferative response and IFN-gamma secretion was found for C-terminal peptides of the protein (Cfp6(51-70), Cfp7(61-80), Cfp8(71-90), and Cfp9(81-100)). The alleles HLA DRB1 *04 and HLA DRB1 *10 recognized the C-terminal peptides Cfp7, Cfp8, and Cfp9 in HHC. Cfp6 was predominantly recognized by the alleles HLA DRB1 *03 and HLA DRB1 *15 by PTB. The minimal nonameric epitopes from the C-terminal region were CFP-10(56-64) and CFP-10(76-84). These two peptides deserve attention for inclusion in a vaccine against tuberculosis in this region.

Entities: Disease Species

Mesh：

Substances：

Year: 2009 PMID： 19902247 DOI： 10.1007/s00430-009-0129-2

Source DB: PubMed Journal: Med Microbiol Immunol ISSN： 0300-8584 Impact factor: 3.402

46 in total

1. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.

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2. Performance of whole blood IFN-gamma test for tuberculosis diagnosis based on PPD or the specific antigens ESAT-6 and CFP-10.

Authors: I Brock; M E Munk; A Kok-Jensen; P Andersen
Journal: Int J Tuberc Lung Dis Date: 2001-05 Impact factor: 2.373

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Authors: M A Behr; P C Hopewell; E A Paz; L M Kawamura; G F Schecter; P M Small
Journal: Am J Respir Crit Care Med Date: 1998-08 Impact factor: 21.405

4. Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

Authors: Homayoun Shams; Peter Klucar; Steven E Weis; Ajit Lalvani; Patrick K Moonan; Hassan Safi; Benjamin Wizel; Katie Ewer; Gerald T Nepom; David M Lewinsohn; Peter Andersen; Peter F Barnes
Journal: J Immunol Date: 2004-08-01 Impact factor: 5.422

5. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG.

Authors: M Harboe; T Oettinger; H G Wiker; I Rosenkrands; P Andersen
Journal: Infect Immun Date: 1996-01 Impact factor: 3.441

6. Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis.

Authors: L Bulat-Kardum; G E Etokebe; J Knezevic; S Balen; N Matakovic-Mileusnic; L Zaputovic; J Pavelic; Z Beg-Zec; Z Dembic
Journal: Scand J Immunol Date: 2006-02 Impact factor: 3.487

7. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Authors: S T Cole; R Brosch; J Parkhill; T Garnier; C Churcher; D Harris; S V Gordon; K Eiglmeier; S Gas; C E Barry; F Tekaia; K Badcock; D Basham; D Brown; T Chillingworth; R Connor; R Davies; K Devlin; T Feltwell; S Gentles; N Hamlin; S Holroyd; T Hornsby; K Jagels; A Krogh; J McLean; S Moule; L Murphy; K Oliver; J Osborne; M A Quail; M A Rajandream; J Rogers; S Rutter; K Seeger; J Skelton; R Squares; S Squares; J E Sulston; K Taylor; S Whitehead; B G Barrell
Journal: Nature Date: 1998-06-11 Impact factor: 49.962

2. Immune response to immunodominant Mycobacterium tuberculosis antigen ESAT-6 derived peptide is HLA-haplotype dependent.

Authors: Michele Smart; Marshall Behrens; Luckey David; Catherine Conway; Veena Taneja
Journal: Jacobs J Allergy Immunol Date: 2014-09-05

2 in total

Cellular immune response to Mycobacterium tuberculosis-specific antigen culture filtrate protein-10 in south India.

1. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection.

2. Performance of whole blood IFN-gamma test for tuberculosis diagnosis based on PPD or the specific antigens ESAT-6 and CFP-10.

3. Predictive value of contact investigation for identifying recent transmission of Mycobacterium tuberculosis.

4. Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles.

5. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG.

6. Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis.

7. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

8. Mapping of multiple HLA class II-restricted T-cell epitopes of the mycobacterial 70-kilodalton heat shock protein.

9. Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection.

10. Multidrug-resistant tuberculosis.

Review 1. Recent publications in medical microbiology and immunology: a retrospective.

2. Immune response to immunodominant Mycobacterium tuberculosis antigen ESAT-6 derived peptide is HLA-haplotype dependent.