Literature DB >> 19902087

Effect of afobazole on mitochondrial monoamine oxidase A activity in vitro.

M V Voronin1, L N Aksenova, O A Buneena, A E Medvedev.   

Abstract

Selective anxiolytic afobazole (1 mM) inhibits monoamine oxidase A activity in mitochondria from rat brain and liver (IC(50) 0.36 and 0.43, respectively). Effect of the compound does not depend on the time of preincubation with mitochondria. Triple washout of mitochondria is followed by complete recovery of initial enzyme activity.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 19902087     DOI: 10.1007/s10517-009-0630-z

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  1 in total

1.  Chaperone Sigma1R mediates the neuroprotective action of afobazole in the 6-OHDA model of Parkinson's disease.

Authors:  Mikhail V Voronin; Ilya A Kadnikov; Dmitry N Voronkov; Sergey B Seredenin
Journal:  Sci Rep       Date:  2019-11-19       Impact factor: 4.379

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.