BACKGROUND: Optical coherence tomography has emerged as a new tool for quantifying axonal loss in multiple sclerosis (MS). A reduction in retinal nerve fiber layer (RNFL) thickness is correlated with Expanded Disability Status Scale score and brain atrophy. OBJECTIVE: To investigate RNFL and macular volume measurements using optical coherence tomography in the clinically isolated syndrome population. DESIGN: Prospective case series. Settings Neurologic clinics at the university hospitals of Lille and Strasbourg (France). PARTICIPANTS: Fifty-six consecutive patients with clinically isolated syndrome (18 with optic neuritis and 38 without optic neuritis) and 32 control subjects. MAIN OUTCOME MEASURES: Macular volume and RNFL thickness. RESULTS: Mean (SD) overall RNFL thickness (98.98 [10.26] microm) and macular volume (6.86 [0.32] microm(3)) in the clinically isolated syndrome population were not significantly different compared with the controls (98.71 [9.08] mum and 6.92 [0.38] microm(3), respectively). No link was noted between atrophy of the RNFL or macula and conversion to MS at 6 months. CONCLUSIONS: Optical coherence tomography does not reveal retinal axonal loss at the earliest clinical stage of MS and does not predict conversion to MS at 6 months.
BACKGROUND: Optical coherence tomography has emerged as a new tool for quantifying axonal loss in multiple sclerosis (MS). A reduction in retinal nerve fiber layer (RNFL) thickness is correlated with Expanded Disability Status Scale score and brain atrophy. OBJECTIVE: To investigate RNFL and macular volume measurements using optical coherence tomography in the clinically isolated syndrome population. DESIGN: Prospective case series. Settings Neurologic clinics at the university hospitals of Lille and Strasbourg (France). PARTICIPANTS: Fifty-six consecutive patients with clinically isolated syndrome (18 with optic neuritis and 38 without optic neuritis) and 32 control subjects. MAIN OUTCOME MEASURES: Macular volume and RNFL thickness. RESULTS: Mean (SD) overall RNFL thickness (98.98 [10.26] microm) and macular volume (6.86 [0.32] microm(3)) in the clinically isolated syndrome population were not significantly different compared with the controls (98.71 [9.08] mum and 6.92 [0.38] microm(3), respectively). No link was noted between atrophy of the RNFL or macula and conversion to MS at 6 months. CONCLUSIONS: Optical coherence tomography does not reveal retinal axonal loss at the earliest clinical stage of MS and does not predict conversion to MS at 6 months.
Authors: Gregory F Wu; Matthew R Brier; Cassie A-L Parks; Beau M Ances; Gregory P Van Stavern Journal: Invest Ophthalmol Vis Sci Date: 2015-04 Impact factor: 4.799
Authors: Hanna G Zimmermann; Benjamin Knier; Timm Oberwahrenbrock; Janina Behrens; Catherina Pfuhl; Lilian Aly; Miriam Kaminski; Muna-Miriam Hoshi; Svenja Specovius; René M Giess; Michael Scheel; Mark Mühlau; Judith Bellmann-Strobl; Klemens Ruprecht; Bernhard Hemmer; Thomas Korn; Friedemann Paul; Alexander U Brandt Journal: JAMA Neurol Date: 2018-09-01 Impact factor: 18.302
Authors: Alexander U Brandt; Hanna Zimmermann; Falko Kaufhold; Julia Promesberger; Sven Schippling; David Finis; Orhan Aktas; Christian Geis; Marius Ringelstein; E Bernd Ringelstein; Hans-Peter Hartung; Friedemann Paul; Ilka Kleffner; Jan Dörr Journal: PLoS One Date: 2012-06-11 Impact factor: 3.240
Authors: Jeffrey M Gelfand; Douglas S Goodin; W John Boscardin; Rachel Nolan; Ami Cuneo; Ari J Green Journal: PLoS One Date: 2012-05-23 Impact factor: 3.240