| Literature DB >> 19899773 |
Phuong-Thien Thuong1, Trong-Tuan Dao, Thi-Hong-Minh Pham, Phi-Hung Nguyen, Thi-Van-Thu Le, Kwang-Youl Lee, Won-Keun Oh.
Abstract
Two new diterpenoids, crotonkinensins A (1) and B (2), were isolated from the leaves of the Vietnamese endemic medicinal plant Croton tonkinensis. Their structures were determined to be 7alpha,10alpha-epoxy-14beta-hydroxygrayanane-1(5),16(17)-dien-2,15-dione (1) and 7alpha,10alpha-epoxy-14beta-hydroxygrayanane-1(2),16(17)-dien-15-one (2) by spectroscopic analysis. Compounds 1 and 2 showed strong anti-inflammatory effects on the LPS-induced COX-2 promoter activity and COX-2 expression in Raw 264.7 cells.Entities:
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Year: 2009 PMID： 19899773 DOI： 10.1021/np900215r
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050