Literature DB >> 19898437

Genentech obtains proof of concept for hedgehog inhibition.

Cormac Sheridan.   

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Year:  2009        PMID: 19898437     DOI: 10.1038/nbt1109-968

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN: 1087-0156            Impact factor:   54.908


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  11 in total

1.  Human homolog of patched, a candidate gene for the basal cell nevus syndrome.

Authors:  R L Johnson; A L Rothman; J Xie; L V Goodrich; J W Bare; J M Bonifas; A G Quinn; R M Myers; D R Cox; E H Epstein; M P Scott
Journal:  Science       Date:  1996-06-14       Impact factor: 47.728

2.  Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.

Authors:  Joel M Hyman; Ari J Firestone; Vivi M Heine; Yun Zhao; Cory A Ocasio; Kyuho Han; Mark Sun; Paul G Rack; Surajit Sinha; Jason J Wu; David E Solow-Cordero; Jin Jiang; David H Rowitch; James K Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-05       Impact factor: 11.205

3.  Hedgehog signaling is dispensable for adult hematopoietic stem cell function.

Authors:  Jie Gao; Stephanie Graves; Ute Koch; Suqing Liu; Vladimir Jankovic; Silvia Buonamici; Abdeljabar El Andaloussi; Stephen D Nimer; Barbara L Kee; Russell Taichman; Freddy Radtke; Iannis Aifantis
Journal:  Cell Stem Cell       Date:  2009-06-05       Impact factor: 24.633

4.  Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

Authors:  H Hahn; C Wicking; P G Zaphiropoulous; M R Gailani; S Shanley; A Chidambaram; I Vorechovsky; E Holmberg; A B Unden; S Gillies; K Negus; I Smyth; C Pressman; D J Leffell; B Gerrard; A M Goldstein; M Dean; R Toftgard; G Chenevix-Trench; B Wainwright; A E Bale
Journal:  Cell       Date:  1996-06-14       Impact factor: 41.582

5.  Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

Authors:  Craig D Peacock; Qiuju Wang; Gregory S Gesell; Ian M Corcoran-Schwartz; Evan Jones; Jynho Kim; Wendy L Devereux; Jonathan T Rhodes; Carol A Huff; Philip A Beachy; D Neil Watkins; William Matsui
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-27       Impact factor: 11.205

6.  Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

Authors:  Kenneth P Olive; Michael A Jacobetz; Christian J Davidson; Aarthi Gopinathan; Dominick McIntyre; Davina Honess; Basetti Madhu; Mae A Goldgraben; Meredith E Caldwell; David Allard; Kristopher K Frese; Gina Denicola; Christine Feig; Chelsea Combs; Stephen P Winter; Heather Ireland-Zecchini; Stefanie Reichelt; William J Howat; Alex Chang; Mousumi Dhara; Lifu Wang; Felix Rückert; Robert Grützmann; Christian Pilarsky; Kamel Izeradjene; Sunil R Hingorani; Pearl Huang; Susan E Davies; William Plunkett; Merrill Egorin; Ralph H Hruban; Nigel Whitebread; Karen McGovern; Julian Adams; Christine Iacobuzio-Donahue; John Griffiths; David A Tuveson
Journal:  Science       Date:  2009-05-21       Impact factor: 47.728

7.  Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.

Authors:  Charles M Rudin; Christine L Hann; John Laterra; Robert L Yauch; Christopher A Callahan; Ling Fu; Thomas Holcomb; Jeremy Stinson; Stephen E Gould; Barbara Coleman; Patricia M LoRusso; Daniel D Von Hoff; Frederic J de Sauvage; Jennifer A Low
Journal:  N Engl J Med       Date:  2009-09-02       Impact factor: 91.245

8.  Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

Authors:  Daniel D Von Hoff; Patricia M LoRusso; Charles M Rudin; Josina C Reddy; Robert L Yauch; Raoul Tibes; Glen J Weiss; Mitesh J Borad; Christine L Hann; Julie R Brahmer; Howard M Mackey; Bertram L Lum; Walter C Darbonne; James C Marsters; Frederic J de Sauvage; Jennifer A Low
Journal:  N Engl J Med       Date:  2009-09-02       Impact factor: 91.245

9.  A small molecule that binds Hedgehog and blocks its signaling in human cells.

Authors:  Benjamin Z Stanton; Lee F Peng; Nicole Maloof; Kazuo Nakai; Xiang Wang; Jay L Duffner; Kennedy M Taveras; Joel M Hyman; Sam W Lee; Angela N Koehler; James K Chen; Julia L Fox; Anna Mandinova; Stuart L Schreiber
Journal:  Nat Chem Biol       Date:  2009-01-18       Impact factor: 15.040

10.  Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

Authors:  Christine Dierks; Ronak Beigi; Gui-Rong Guo; Katja Zirlik; Mario R Stegert; Paul Manley; Christopher Trussell; Annette Schmitt-Graeff; Klemens Landwerlin; Hendrik Veelken; Markus Warmuth
Journal:  Cancer Cell       Date:  2008-09-09       Impact factor: 31.743

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  5 in total

Review 1.  Development of an effective therapy for chronic myelogenous leukemia.

Authors:  David W Woessner; Carol S Lim; Michael W Deininger
Journal:  Cancer J       Date:  2011 Nov-Dec       Impact factor: 3.360

2.  Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors.

Authors:  Jeffrey D Winkler; André K Isaacs; Chaomei Xiang; Valérie Baubet; Nadia Dahmane
Journal:  Tetrahedron       Date:  2011-12-30       Impact factor: 2.457

3.  Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of Hedgehog signaling based on cyclopamine.

Authors:  Zhihui Zhang; Valérie Baubet; Christian Ventocilla; Chaomei Xiang; Nadia Dahmane; Jeffrey D Winkler
Journal:  Org Lett       Date:  2011-08-15       Impact factor: 6.005

4.  Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression.

Authors:  James S Hale; Balint Otvos; Maksim Sinyuk; Alvaro G Alvarado; Masahiro Hitomi; Kevin Stoltz; Qiulian Wu; William Flavahan; Bruce Levison; Mette L Johansen; David Schmitt; Janna M Neltner; Ping Huang; Bin Ren; Andrew E Sloan; Roy L Silverstein; Candece L Gladson; Joseph A DiDonato; J Mark Brown; Thomas McIntyre; Stanley L Hazen; Craig Horbinski; Jeremy N Rich; Justin D Lathia
Journal:  Stem Cells       Date:  2014-07       Impact factor: 6.277

5.  Thrombospondin-1/CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic hedgehog pathway suppression.

Authors:  Jie-Mei Wang; Jeffery S Isenberg; Timothy R Billiar; Alex F Chen
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-10-22       Impact factor: 4.310

  5 in total

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