OBJECTIVE: to determine the prevalence of orthostatic hypotension (OH) and associations with medication use in community-dwelling older women. DESIGN: cross-sectional analysis using data from the British Women's Heart and Health Study. SETTING: general practices in 23 towns in the UK. PARTICIPANTS: 3,775 women aged 60-80 years from 1999 to 2001. MAIN OUTCOME MEASURE: orthostatic hypotension-drop of > or =20 mmHg in systolic and/or a drop of > or =10 mmHg in diastolic blood pressure on standing. RESULTS: prevalence of OH was 28% (95% confidence interval [CI] 26.6, 29.4), which increased with age and hypertension. Regardless of treatment status or diagnosed hypertension, raised blood pressure was strongly associated with OH (P < 0.001). OH was strongly associated with number of antihypertensives taken (none vs three or more: odds ratio [OR] 2.24, 95% CI 1.47-3.40, P < 0.001); the association was slightly attenuated after allowing for age and co-morbidities (OR 1.99; 95% CI 1.30, 3.05; P = 0.003). Women with multiple co-morbidities had markedly increased odds of OH independent of age, number and type of medications taken (none vs four or more diagnoses: OR 2.28, 95% CI 1.58-3.30, P = 0.005). CONCLUSION: uncontrolled hypertension, use of three or more antihypertensives and multiple co-morbidities are predictors of OH in older women. Detection or monitoring of OH in these groups may prevent women from suffering its adverse consequences.
OBJECTIVE: to determine the prevalence of orthostatic hypotension (OH) and associations with medication use in community-dwelling older women. DESIGN: cross-sectional analysis using data from the British Women's Heart and Health Study. SETTING: general practices in 23 towns in the UK. PARTICIPANTS: 3,775 women aged 60-80 years from 1999 to 2001. MAIN OUTCOME MEASURE: orthostatic hypotension-drop of > or =20 mmHg in systolic and/or a drop of > or =10 mmHg in diastolic blood pressure on standing. RESULTS: prevalence of OH was 28% (95% confidence interval [CI] 26.6, 29.4), which increased with age and hypertension. Regardless of treatment status or diagnosed hypertension, raised blood pressure was strongly associated with OH (P < 0.001). OH was strongly associated with number of antihypertensives taken (none vs three or more: odds ratio [OR] 2.24, 95% CI 1.47-3.40, P < 0.001); the association was slightly attenuated after allowing for age and co-morbidities (OR 1.99; 95% CI 1.30, 3.05; P = 0.003). Women with multiple co-morbidities had markedly increased odds of OH independent of age, number and type of medications taken (none vs four or more diagnoses: OR 2.28, 95% CI 1.58-3.30, P = 0.005). CONCLUSION: uncontrolled hypertension, use of three or more antihypertensives and multiple co-morbidities are predictors of OH in older women. Detection or monitoring of OH in these groups may prevent women from suffering its adverse consequences.
Authors: C Di Stefano; V Milazzo; S Totaro; G Sobrero; A Ravera; A Milan; S Maule; F Veglio Journal: J Hum Hypertens Date: 2015-01-29 Impact factor: 3.012
Authors: Karen L Margolis; Lisa Palermo; Eric Vittinghoff; Gregory W Evans; Hal H Atkinson; Bruce P Hamilton; Robert G Josse; Patrick J O'Connor; Debra L Simmons; Margaret Tiktin; Ann V Schwartz Journal: J Gen Intern Med Date: 2014-08-16 Impact factor: 5.128
Authors: Stephen P Juraschek; Lawrence J Appel; Edgar R Miller; Kenneth J Mukamal; Lewis A Lipsitz Journal: Hypertension Date: 2018-10 Impact factor: 10.190