Literature DB >> 19896966

The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.

Alan P Fields1, Verline Justilien.   

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Year:  2009        PMID： 19896966      PMCID： PMC2863999          DOI： 10.1016/j.advenzreg.2009.10.010

Source DB:  PubMed          Journal:  Adv Enzyme Regul        ISSN： 0065-2571


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  56 in total

1.  RhoG signals in parallel with Rac1 and Cdc42.

Authors:  Krister Wennerberg; Shawn M Ellerbroek; Rong-Yu Liu; Antoine E Karnoub; Keith Burridge; Channing J Der
Journal:  J Biol Chem       Date:  2002-10-09       Impact factor: 5.157

2.  Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.

Authors:  Patricia A Solski; Rhonda S Wilder; Kent L Rossman; John Sondek; Adrienne D Cox; Sharon L Campbell; Channing J Der
Journal:  J Biol Chem       Date:  2004-04-08       Impact factor: 5.157

3.  Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

Authors:  Astrid M Eder; Xiaomei Sui; Daniel G Rosen; Laura K Nolden; Kwai Wa Cheng; John P Lahad; Madhuri Kango-Singh; Karen H Lu; Carla L Warneke; Edward N Atkinson; Isabelle Bedrosian; Khandan Keyomarsi; Wen-lin Kuo; Joe W Gray; Jerry C P Yin; Jinsong Liu; Georg Halder; Gordon B Mills
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-22       Impact factor: 11.205

4.  Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity.

Authors:  Roderick P Regala; Capella Weems; Lee Jamieson; John A Copland; E Aubrey Thompson; Alan P Fields
Journal:  J Biol Chem       Date:  2005-07-01       Impact factor: 5.157

5.  Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines.

Authors:  Farrah Clemens; Rini Verma; Jamuna Ramnath; Joseph R Landolph
Journal:  Toxicol Appl Pharmacol       Date:  2005-08-07       Impact factor: 4.219

6.  Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung carcinomas.

Authors:  B R Balsara; G Sonoda; S du Manoir; J M Siegfried; E Gabrielson; J R Testa
Journal:  Cancer Res       Date:  1997-06-01       Impact factor: 12.701

7.  Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

Authors:  L H Thompson; K W Brookman; N J Jones; S A Allen; A V Carrano
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

8.  Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.

Authors:  F Niiya; T Tatsumoto; K S Lee; T Miki
Journal:  Oncogene       Date:  2006-02-09       Impact factor: 9.867

Review 9.  Rho GTPase expression in tumourigenesis: evidence for a significant link.

Authors:  Teresa Gómez del Pulgar; Salvador A Benitah; Pilar F Valerón; Carolina Espina; Juan Carlos Lacal
Journal:  Bioessays       Date:  2005-06       Impact factor: 4.345

10.  Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.

Authors:  L A Frederick; J A Matthews; L Jamieson; V Justilien; E A Thompson; D C Radisky; A P Fields
Journal:  Oncogene       Date:  2008-04-21       Impact factor: 9.867
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  56 in total

1.  Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells.

Authors:  Verline Justilien; Kayla C Lewis; Kayleah M Meneses; Lee Jamieson; Nicole R Murray; Alan P Fields
Journal:  J Biol Chem       Date:  2020-04-29       Impact factor: 5.157

2.  FXR1 is elevated in colorectal cancer and acts as an oncogene.

Authors:  Xin Jin; Bo Zhai; Taishi Fang; Xiaohui Guo; Lishan Xu
Journal:  Tumour Biol       Date:  2015-09-24

3.  Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

Authors:  Shai Mulinari; Udo Häcker
Journal:  Small GTPases       Date:  2010-07

4.  The chromosome 3q26 OncCassette: A multigenic driver of human cancer.

Authors:  Alan P Fields; Verline Justilien; Nicole R Murray
Journal:  Adv Biol Regul       Date:  2015-12-23

5.  Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.

Authors:  Yuan Gao; Elenoe Smith; Elmer Ker; Phil Campbell; Ee-chun Cheng; Siying Zou; Sharon Lin; Lin Wang; Stephanie Halene; Diane S Krause
Journal:  Dev Cell       Date:  2012-03-01       Impact factor: 12.270

6.  Tyrosine phosphorylation of Dbl regulates GTPase signaling.

Authors:  Meghana Gupta; Xiaojun Qi; Varsha Thakur; Danny Manor
Journal:  J Biol Chem       Date:  2014-04-28       Impact factor: 5.157

7.  Mechanisms of CDC-42 activation during contact-induced cell polarization.

Authors:  Emily Chan; Jeremy Nance
Journal:  J Cell Sci       Date:  2013-02-19       Impact factor: 5.285

8.  Clinical significance of ECT2 expression in tissue and serum of gastric cancer patients.

Authors:  H-B Wang; H-C Yan; Y Liu
Journal:  Clin Transl Oncol       Date:  2015-10-26       Impact factor: 3.405

9.  Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.

Authors:  Elisabeth R Greer; Anna T Chao; Amy Bejsovec
Journal:  Development       Date:  2013-11-06       Impact factor: 6.868

10.  Molecular cytogenetics as a clinical test for prognostic and predictive biomarkers in newly diagnosed ovarian cancer.

Authors:  Shelly Gunn; Xavier Reveles; Korrie Weldon; Andres Barrera; Mariam Ishaque; Dale Taylor; Chris McCaskill; Jaeweon Kim; Rashmi Shah; Mansoor Mohammed; Todd Barry; Brianne Kaiser; Amita Patnaik; Anthony Tolcher
Journal:  J Ovarian Res       Date:  2013-01-04       Impact factor: 4.234
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