| Literature DB >> 19896844 |
T David Bateman1, Aarti L Joshi, Kwangyul Moon, Elena N Galitovskaya, Meenakshi Upreti, Timothy C Chambers, Matthias C McIntosh.
Abstract
Three structurally related sets of hydroisobenzofuran analogs of sclerophytin A were prepared in three or four steps from (S)-(+)-carvone via an aldol-cycloaldol sequence. The most potent members of each set of analogs exhibited IC(50)'s of 1-3 microM in growth inhibitory assays against KB3 cells. The NCI 60-cell line 5-dose assay for analog 6h revealed a GI(50)=0.148 microM and LC(50)=9.36 microM for the RPMI-8226 leukemia cell line, and a GI(50)=0.552 microM and LC(50)=26.8 microM for the HOP-92 non-small cell lung cancer cell line.Entities:
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Year: 2009 PMID： 19896844 PMCID： PMC3276365 DOI： 10.1016/j.bmcl.2009.10.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823