| Literature DB >> 19896843 |
Jiwen Liu1, Yingcai Wang, Ying Sun, Derek Marshall, Shichang Miao, George Tonn, Penny Anders, Joel Tocker, H Lucy Tang, Julio Medina.
Abstract
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 antagonists.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19896843 DOI： 10.1016/j.bmcl.2009.10.094
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823