Literature DB >> 1989620

Elafin is a potent inhibitor of proteinase 3.

O Wiedow1, J Lüademann, B Utecht.   

Abstract

Elafin, a human skin derived inhibitor of human leukocyte elastase, was tested for inhibitory activity against proteinase 3, an elastin degrading proteinase of neutrophils. The inhibitory activity of elafin was compared with antileukoprotease and eglin C. Elafin proved to be a potent inhibitor of elastin-FITC degradation showing an IC 50 of 9.5 x 10(-9) M. Potency was found to be more than 100-fold higher as compared with antileukoprotease and eglin C.

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Year:  1991        PMID： 1989620     DOI： 10.1016/0006-291x(91)90476-n

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

1.  Skin-derived antileukoproteinase (SKALP) is decreased in pustular forms of psoriasis. A clue to the pathogenesis of pustule formation?

Authors:  A L Kuijpers; P L Zeeuwen; G J de Jongh; P C van de Kerkhof; H A Alkemade; J Schalkwijk
Journal:  Arch Dermatol Res       Date:  1996-10       Impact factor: 3.017

2.  Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion.

Authors:  Fethia Ben Yebdri; Filip Kukulski; Alain Tremblay; Jean Sévigny
Journal:  Eur J Immunol       Date:  2009-10       Impact factor: 5.532

3.  Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.

Authors:  Sixin Tian; Joakim E Swedberg; Choi Yi Li; David J Craik; Simon J de Veer
Journal:  ACS Med Chem Lett       Date:  2019-07-19       Impact factor: 4.345

4.  Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.

Authors:  Nils P Nickel; Edda Spiekerkoetter; Mingxia Gu; Caiyun G Li; Hai Li; Mark Kaschwich; Isabel Diebold; Jan K Hennigs; Ki-Yoon Kim; Kazuya Miyagawa; Lingli Wang; Aiqin Cao; Silin Sa; Xinguo Jiang; Raymond W Stockstill; Mark R Nicolls; Roham T Zamanian; Richard D Bland; Marlene Rabinovitch
Journal:  Am J Respir Crit Care Med       Date:  2015-06-01       Impact factor: 21.405

Review 5.  Neutrophil elastase inhibitors.

Authors:  William C Groutas; Dengfeng Dou; Kevin R Alliston
Journal:  Expert Opin Ther Pat       Date:  2011-01-16       Impact factor: 6.674

6.  Differential expression of SKALP/Elafin in human epidermal tumors.

Authors:  H A Alkemade; H O Molhuizen; I M van Vlijmen-Willems; U J van Haelst; J Schalkwijk
Journal:  Am J Pathol       Date:  1993-12       Impact factor: 4.307

7.  Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation.

Authors:  B Cowan; O Baron; J Crack; C Coulber; G J Wilson; M Rabinovitch
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

8.  Evolution of trappin genes in mammals.

Authors:  Akira Kato; Alejandro P Rooney; Yutaka Furutani; Shigehisa Hirose
Journal:  BMC Evol Biol       Date:  2010-01-29       Impact factor: 3.260

9.  Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia.

Authors:  R Pfundt; F van Ruissen; I M van Vlijmen-Willems; H A Alkemade; P L Zeeuwen; P H Jap; H Dijkman; J Fransen; H Croes; P E van Erp; J Schalkwijk
Journal:  J Clin Invest       Date:  1996-09-15       Impact factor: 14.808

10.  Expression of SKALP/elafin during wound healing in human skin.

Authors:  B H van Bergen; M P Andriessen; K I Spruijt; P C van de Kerkhof; J Schalkwijk
Journal:  Arch Dermatol Res       Date:  1996-07       Impact factor: 3.017
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