| Literature DB >> 19896186 |
Virginie Gandemer1, Marc Aubry, Mikael Roussel, Anne-Gaelle Rio, Marie de Tayrac, Audrey Vallee, Jean Mosser, Béatrice Ly-Sunnaram, Marie-Dominique Galibert.
Abstract
CD9 has been shown to be differentially expressed in childhood TEL/AML1-positive acute lymphoblastic leukemia (ALL). We confirmed this finding in large Affymetrix data sets and in 80 new cases at both RNA and protein levels. Moreover, we showed that mean fluorescence intensity of CD9 by flow cytometry can distinguish TEL/AML1-positive ALL from other BCP-ALL. Using ROC analysis, the most efficient model for predicting TEL/AML1-positive ALL combined CD9 (mean fluorescence intensity <or=20) and CD10 values (positive cells >40%). Finally, we propose a faster procedure for optimizing the diagnosis of childhood BCP-ALL subgroups. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19896186 DOI： 10.1016/j.leukres.2009.09.033
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156