Literature DB >> 1989612

Demonstration of extrinsic DNA from immune complexes in plasma of a patient with systemic lupus erythematosus.

K Terada1, E Okuhara, Y Kawarada, S Hirose.   

Abstract

Antigen DNA isolated from immune complexes present in plasma of three patients with active systemic lupus erythematosus using an affinity column was cloned and sequenced. One clone, designated pKS7, was found to have a region homologous with that of the E. coli metK gene, and another, designated pKS8, had a region homologous with a sequence including the replication origin of bacteriophage f1. Gel retardation assay revealed that pKS7 and pKS8 interacted with the patient's IgG fraction to form immune complexes, respectively. The affinity-purified antigen DNA was proved to be originated from bacteria or bacteriophage.

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Year:  1991        PMID： 1989612     DOI： 10.1016/0006-291x(91)90523-a

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-07-25       Impact factor: 16.971

2.  Complexes of serum amyloid P component and DNA in serum from healthy individuals and systemic lupus erythematosus patients.

Authors:  I J Sørensen; E Holm Nielsen; L Schrøder; A Voss; L Horváth; S E Svehag
Journal:  J Clin Immunol       Date:  2000-11       Impact factor: 8.317

3.  Retroviruses in rheumatic diseases.

Authors:  P N Nelson
Journal:  Ann Rheum Dis       Date:  1995-06       Impact factor: 19.103

Review 4.  CpG DNA: a pathogenic factor in systemic lupus erythematosus?

Authors:  A M Krieg
Journal:  J Clin Immunol       Date:  1995-11       Impact factor: 8.317

5.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-07-11       Impact factor: 16.971
  5 in total

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