Literature DB >> 1989582

Products and intermediates of the beta-oxidation of [U-14C]hexadecanedionoyl-mono-CoA by rat liver peroxisomes and mitochondria.

M Pourfarzam1, K Bartlett.   

Abstract

1. The synthesis of [U-14C]hexadecanedionoyl-mono-CoA is described. 2. The beta-oxidation of [U-14C]hexadecanedionoyl-mono-CoA by purified rat liver peroxisomes and mitochondria is demonstrated. 3. The products of mitochondrial beta-oxidation of [U-14C]hexadecanedionoyl-mono-CoA include ketone bodies, citrate and acetylcarnitine. 4. Tetradecadionoyl-mono-CoA, hexadec-2-enedionyl-mono-CoA and hexadionoyl-mono-CoA were the only detectable intermediates formed by mitochondrial beta-oxidation, whereas acetyl-CoA and all saturated even-numbered intermediates of chain length C6-C16 were generated by peroxisomal beta-oxidation. 5. Hexadecanedionoyl-mono-CoA and hexadecanoyl-CoA were equally effective substrates for peroxisomal beta-oxidation, but hexadecanedionoyl-mono-CoA was a relatively poorer substrate for the mitochondrial pathway.

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Year:  1991        PMID： 1989582      PMCID： PMC1149900          DOI： 10.1042/bj2730205

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Measurement of the acyl-CoA intermediates of beta-oxidation by h.p.l.c. with on-line radiochemical and photodiode-array detection. Application to the study of [U-14C]hexadecanoate oxidation by intact rat liver mitochondria.

Authors:  N J Watmough; D M Turnbull; H S Sherratt; K Bartlett
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

2.  General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases.

Authors:  N Gregersen; S Kølvraa; K Rasmussen; P B Mortensen; P Divry; M David; N Hobolth
Journal:  Clin Chim Acta       Date:  1983-08-15       Impact factor: 3.786

3.  A study of the metabolism of [U-14C]3-methyl-2-oxopentanoate by rat liver mitochondria using h.p.l.c. with continuous on-line monitoring of radioactive intact acyl-coenzyme A intermediates.

Authors:  A G Causey; B Middleton; K Bartlett
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

4.  Skeletal muscle mitochondrial beta-oxidation. A study of the products of oxidation of [U-14C]hexadecanoate by h.p.l.c. using continuous on-line radiochemical detection.

Authors:  N J Watmough; A K Bhuiyan; K Bartlett; H S Sherratt; D M Turnbull
Journal:  Biochem J       Date:  1988-07-15       Impact factor: 3.857

5.  In situ metabolism of 1,omega medium chain dicarboxylic acids in the liver of intact rats as detected by 13C and 1H NMR.

Authors:  S Cerdan; B Künnecke; A Dölle; J Seelig
Journal:  J Biol Chem       Date:  1988-08-25       Impact factor: 5.157

6.  The biological origin of ketotic dicarboxylic aciduria. In vivo and in vitro investigations of the omega-oxidation of C6-C16-monocarboxylic acids in unstarved, starved and diabetic rats.

Authors:  P B Mortensen; N Gregersen
Journal:  Biochim Biophys Acta       Date:  1981-12-23

7.  Interactions between the omega- and beta-oxidations of fatty acids.

Authors:  J Vamecq; J P Draye
Journal:  J Biochem       Date:  1987-07       Impact factor: 3.387

8.  The biological origin of ketotic dicarboxylic aciduria. II. In vivo and in vitro investigations of the beta-oxidation of C8-C16-dicarboxylic acids in unstarved, starved and diabetic rats.

Authors:  P B Mortensen; N Gregersen
Journal:  Biochim Biophys Acta       Date:  1982-03-12

9.  In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver.

Authors:  S Kølvraa; N Gregersen
Journal:  Biochim Biophys Acta       Date:  1986-05-21

10.  The oxidation of dicarboxylic acid CoA esters via peroxisomal fatty acyl-CoA oxidase.

Authors:  M S Poosch; R K Yamazaki
Journal:  Biochim Biophys Acta       Date:  1989-12-18
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  7 in total

1.  Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids.

Authors:  Sander M Houten; Simone Denis; Carmen A Argmann; Yuzhi Jia; Sacha Ferdinandusse; Janardan K Reddy; Ronald J A Wanders
Journal:  J Lipid Res       Date:  2012-04-25       Impact factor: 5.922

2.  Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets.

Authors:  X Lin; S H Adams; J Odle
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

3.  Long-chain acyl-CoA ester intermediates of beta-oxidation of mono- and di-carboxylic fatty acids by extracts of Corynebacterium sp. strain 7E1C.

Authors:  N M Broadway; F M Dickinson; C Ratledge
Journal:  Biochem J       Date:  1992-07-01       Impact factor: 3.857

Review 4.  Metabolic interactions between peroxisomes and mitochondria with a special focus on acylcarnitine metabolism.

Authors:  Sander M Houten; Ronald J A Wanders; Pablo Ranea-Robles
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2020-02-10       Impact factor: 5.187

5.  Metabolic consequences of methylenecyclopropylglycine poisoning in rats.

Authors:  K Melde; S Jackson; K Bartlett; H S Sherratt; S Ghisla
Journal:  Biochem J       Date:  1991-03-01       Impact factor: 3.857

6.  Intramitochondrial control of the oxidation of hexadecanoate in skeletal muscle. A study of the acyl-CoA esters which accumulate during rat skeletal-muscle mitochondrial beta-oxidation of [U-14C]hexadecanoate and [U-14C]hexadecanoyl-carnitine.

Authors:  S Eaton; A K Bhuiyan; R S Kler; D M Turnbull; K Bartlett
Journal:  Biochem J       Date:  1993-01-01       Impact factor: 3.857

7.  The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis.

Authors:  Pablo Ranea-Robles; Hongjie Chen; Brandon Stauffer; Chunli Yu; Dipankar Bhattacharya; Scott L Friedman; Michelle Puchowicz; Sander M Houten
Journal:  J Inherit Metab Dis       Date:  2021-10-02       Impact factor: 4.982
  7 in total

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