OBJECTIVE: To determine whether the association between family history of diabetes (FHD) and impaired fasting glucose (IFG) is independent of body mass index (BMI) in children and adolescents. METHODS: In all 443 (11.9%) children and adolescents with FHD, and 3280 (88.1%) without FHD were enrolled in a population-based cross-sectional study. Eligible subjects to participate were apparently healthy children and adolescents aged 7-15 yr from Middle and Northern Mexico. Obesity was defined by age- and gender-specific BMI >or= 95th percentile. FHD was defined as positive if at least one first degree relative had diabetes. The IFG was defined by fasting plasma glucose >or= 100 mg/dL and < 126 mg/dL. RESULTS: IFG was identified in 390 (88.0%) and 62 (1.9%) children and adolescents with and without FHD, respectively. In the group with positive FHD, IFG was diagnosed in 146 (37.4%), 79 (20.2%), and 165 (42.3%) children and adolescents who were obese, overweight, and normal-weight, respectively. On the other hand, in the group without FHD, IFG was identified in 21 (33.9%), 14 (22.6%), and 27 (43.5%) children and adolescents who were obese, overweight, and normal-weight, respectively. In the overall population, the age-, sex-, and BMI-adjusted logistic regression analysis showed a strong and independent association between FHD and IFG [odds ratio (OR) -11.7; 95% CI 9.5-21.2]. This association remained strong for girls and boys in a subsequent analysis stratified for BMI category. CONCLUSIONS: The presence of FHD in a first degree relative is associated with IFG, even in the absence of obesity.
OBJECTIVE: To determine whether the association between family history of diabetes (FHD) and impaired fasting glucose (IFG) is independent of body mass index (BMI) in children and adolescents. METHODS: In all 443 (11.9%) children and adolescents with FHD, and 3280 (88.1%) without FHD were enrolled in a population-based cross-sectional study. Eligible subjects to participate were apparently healthy children and adolescents aged 7-15 yr from Middle and Northern Mexico. Obesity was defined by age- and gender-specific BMI >or= 95th percentile. FHD was defined as positive if at least one first degree relative had diabetes. The IFG was defined by fasting plasma glucose >or= 100 mg/dL and < 126 mg/dL. RESULTS: IFG was identified in 390 (88.0%) and 62 (1.9%) children and adolescents with and without FHD, respectively. In the group with positive FHD, IFG was diagnosed in 146 (37.4%), 79 (20.2%), and 165 (42.3%) children and adolescents who were obese, overweight, and normal-weight, respectively. On the other hand, in the group without FHD, IFG was identified in 21 (33.9%), 14 (22.6%), and 27 (43.5%) children and adolescents who were obese, overweight, and normal-weight, respectively. In the overall population, the age-, sex-, and BMI-adjusted logistic regression analysis showed a strong and independent association between FHD and IFG [odds ratio (OR) -11.7; 95% CI 9.5-21.2]. This association remained strong for girls and boys in a subsequent analysis stratified for BMI category. CONCLUSIONS: The presence of FHD in a first degree relative is associated with IFG, even in the absence of obesity.
Authors: Anna-Lena Volckmar; Jie-Yun Song; Ivonne Jarick; Carolin Pütter; Maria Göbel; Lucie Horn; Christoph Struve; Katharina Haas; Nadja Knoll; Harald Grallert; Thomas Illig; Thomas Reinehr; Hai-Jun Wang; Johannes Hebebrand; Anke Hinney Journal: PLoS One Date: 2015-05-08 Impact factor: 3.240
Authors: Yutian Yin; Weiqing Han; Yuhan Wang; Yue Zhang; Shili Wu; Huiping Zhang; Lingling Jiang; Rui Wang; Peng Zhang; Yaqin Yu; Bo Li Journal: Int J Environ Res Public Health Date: 2015-10-12 Impact factor: 3.390
Authors: Celia Aradillas-Garc X Cd; Miguel Cruz; Elva Pérez-Luque; María E Garay-Sevilla; Juan M Malacara; Aduna R; Jesús Peralta; Ana Burguete-García; Jorge A Alegría-Torres Journal: J Biomed Res Date: 2016-10-17