OBJECTIVE: To study the chemical constituents from the 60% ethanol extract of Corydalis yanhusuo. METHOD: The chemical constituents were separated and purified by various chromatographic techniques, and their structures were elucidated by chemical evidence and spectroscopic analysis. RESULT: Nine alkaloids were obtained and determined as 7-formyldidehydroglaucine (1), nantenine (2), (+)-O-methylbulbocapnine (3), d-corydaline (4), tetrahydrocoptisine (5), 8-oxocoptisine (6), palmatine (7), tetrahydropalmatine (8), and dehydrocorydaline (9), respectively. CONCLUSION: Compound 1 was obtained from natural products for the first time, and its NMR data were firstly reported. Compound 3 was reported from Papaveraceae for the first time, and compound 6 was firstly reported from Corydalis yanhusuo.
OBJECTIVE: To study the chemical constituents from the 60% ethanol extract of Corydalis yanhusuo. METHOD: The chemical constituents were separated and purified by various chromatographic techniques, and their structures were elucidated by chemical evidence and spectroscopic analysis. RESULT: Nine alkaloids were obtained and determined as 7-formyldidehydroglaucine (1), nantenine (2), (+)-O-methylbulbocapnine (3), d-corydaline (4), tetrahydrocoptisine (5), 8-oxocoptisine (6), palmatine (7), tetrahydropalmatine (8), and dehydrocorydaline (9), respectively. CONCLUSION: Compound 1 was obtained from natural products for the first time, and its NMR data were firstly reported. Compound 3 was reported from Papaveraceae for the first time, and compound 6 was firstly reported from Corydalis yanhusuo.
Authors: Ronald J Y Chen; Tzyy-rong Jinn; Yi-ching Chen; Tse-yu Chung; Wei-hung Yang; Jason T C Tzen Journal: Acta Pharmacol Sin Date: 2011-02 Impact factor: 6.150