Literature DB >> 19894114

Intrastriatal transplantation of GDNF-engineered BMSCs and its neuroprotection in lactacystin-induced Parkinsonian rat model.

Jianjun Wu1, Wenbo Yu, Yan Chen, Yaru Su, Zhengtong Ding, Huimin Ren, Yuping Jiang, Jian Wang.   

Abstract

The potential value of glial cell line-derived neurotrophic factor (GDNF) in treating Parkinson's disease (PD) remains controversial. In order to evaluate the therapeutic effect of GDNF-engineered bone marrow stromal cells (BMSCs) in parkinsonian rat model, GDNF-BMSCs and LacZ-BMSCs were transplanted into striatum and followed by Lactacystin lesioning at median forebrain bundles 1 week later. We observed that the intrastriatal transplantation of GDNF-BMSCs could significantly rescue the dopaminergic neurons from lactacystin-induced neurotoxicity with regard to behavioral recovery, tyrosine hydroxylase level in nigra and striatum, and striatal dopamine level. We interpret the outcomes that intrastriatal transplantation of GDNF-BMSCs might be beneficial in the treatment of PD.

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Year:  2009        PMID： 19894114     DOI： 10.1007/s11064-009-0086-6

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  35 in total

1.  Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition.

Authors:  Hardy J Rideout; Isabelle C J Lang-Rollin; Magali Savalle; Leonidas Stefanis
Journal:  J Neurochem       Date:  2005-06       Impact factor: 5.372

2.  Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats.

Authors:  Bai-Yun Zeng; Salma Bukhatwa; Atsuko Hikima; Sarah Rose; Peter Jenner
Journal:  Ann Neurol       Date:  2006-08       Impact factor: 10.422

Review 3.  The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders.

Authors:  K K Chung; V L Dawson; T M Dawson
Journal:  Trends Neurosci       Date:  2001-11       Impact factor: 13.837

4.  Application of a blood-brain-barrier-penetrating form of GDNF in a mouse model for Parkinson's disease.

Authors:  Gunnar P H Dietz; Paoloa C Valbuena; Birgit Dietz; Katrin Meuer; Patrick Müeller; Jachen H Weishaupt; Mathias Bähr
Journal:  Brain Res       Date:  2006-04-12       Impact factor: 3.252

Review 5.  Synucleinopathies: clinical and pathological implications.

Authors:  J E Galvin; V M Lee; J Q Trojanowski
Journal:  Arch Neurol       Date:  2001-02

Review 6.  Emerging restorative treatments for Parkinson's disease.

Authors:  Tomas Deierborg; Denis Soulet; Laurent Roybon; Vanessa Hall; Patrik Brundin
Journal:  Prog Neurobiol       Date:  2008-05-14       Impact factor: 11.685

7.  Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo.

Authors:  Tianhong Pan; Wen Zhu; Hongru Zhao; Hao Deng; Wenjie Xie; Joseph Jankovic; Weidong Le
Journal:  Brain Res       Date:  2008-05-20       Impact factor: 3.252

8.  Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystin.

Authors:  Ya-Ru Su; Jian Wang; Jian-Jun Wu; Yan Chen; Yu-Ping Jiang
Journal:  Neurosci Bull       Date:  2007-03       Impact factor: 5.203

9.  Therapeutic effect of microencapsulated porcine retinal pigmented epithelial cells transplantation on rat model of Parkinson's disease.

Authors:  Hou-Liang Zhang; Jian-Jun Wu; Hui-Min Ren; Jian Wang; Ya-Ru Su; Yu-Ping Jiang
Journal:  Neurosci Bull       Date:  2007-05       Impact factor: 5.203

10.  Altered proteasomal function in sporadic Parkinson's disease.

Authors:  Kevin St P McNaught; Roger Belizaire; Ole Isacson; Peter Jenner; C Warren Olanow
Journal:  Exp Neurol       Date:  2003-01       Impact factor: 5.330
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  15 in total

1.  Comparing neuroprotective effects of CDNF-expressing bone marrow derived mesenchymal stem cells via differing routes of administration utilizing an in vivo model of Parkinson's disease.

Authors:  Mei Jiaming; Chaoshi Niu
Journal:  Neurol Sci       Date:  2014-08-27       Impact factor: 3.307

2.  The TrkB-positive dopaminergic neurons are less sensitive to MPTP insult in the substantia nigra of adult C57/BL mice.

Authors:  Yin-Xiu Ding; Yi Xia; Xi-Ying Jiao; Li Duan; Jun Yu; Xi Wang; Liang-Wei Chen
Journal:  Neurochem Res       Date:  2011-05-12       Impact factor: 3.996

3.  Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.

Authors:  Dan-Mei Lan; Feng-Tao Liu; Jian Zhao; Yan Chen; Jian-Jun Wu; Zheng-Tong Ding; Zhen-Yu Yue; Hui-Min Ren; Yu-Ping Jiang; Jian Wang
Journal:  Neurochem Res       Date:  2012-06-17       Impact factor: 3.996

4.  Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor.

Authors:  Xianwu Li; Eiron Cudaback; Richard M Breyer; Kathleen S Montine; C Dirk Keene; Thomas J Montine
Journal:  FASEB J       Date:  2012-04-12       Impact factor: 5.191

Review 5.  Potential Role of Growth Factors Controlled Release in Achieving Enhanced Neuronal Trans-differentiation from Mesenchymal Stem Cells for Neural Tissue Repair and Regeneration.

Authors:  Ayushi Gupta; Sangeeta Singh
Journal:  Mol Neurobiol       Date:  2021-11-24       Impact factor: 5.590

Review 6.  Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases.

Authors:  Robert D Wyse; Gary L Dunbar; Julien Rossignol
Journal:  Int J Mol Sci       Date:  2014-01-23       Impact factor: 5.923

Review 7.  Advances in treatment of neurodegenerative diseases: Perspectives for combination of stem cells with neurotrophic factors.

Authors:  Jie Wang; Wei-Wei Hu; Zhi Jiang; Mei-Jiang Feng
Journal:  World J Stem Cells       Date:  2020-05-26       Impact factor: 5.326

8.  Parkinson's disease and mesenchymal stem cells: potential for cell-based therapy.

Authors:  Masaaki Kitada; Mari Dezawa
Journal:  Parkinsons Dis       Date:  2012-02-28

9.  Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults.

Authors:  Yi Xia; Bei-Yu Chen; Xiao-Long Sun; Li Duan; Guo-Dong Gao; Jing-Jie Wang; Ken Kam-Lin Yung; Liang-Wei Chen
Journal:  Int J Mol Sci       Date:  2013-07-08       Impact factor: 5.923

10.  Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.

Authors:  Yang Hu; Yan Zhang; Kang Tian; Chong Xun; Shouyu Wang; Decheng Lv
Journal:  Mol Med Rep       Date:  2015-11-11       Impact factor: 2.952
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