Literature DB >> 19892809

Apical potassium (BK) channels and enhanced potassium secretion in human colon.

G I Sandle1, M Hunter.   

Abstract

The human colon has the capacity to secrete potassium (K(+)) ions and enhanced K(+) secretion is a feature of a variety of diarrhoeal diseases. Recent work points to K(+) secretion in human colon being mediated by high conductance (BK) K(+) channels located in the apical membrane of colonic epithelial cells. The aim of this review is to highlight the importance of these channels in maintaining K(+) homoeostasis in health and disease.

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Year:  2009        PMID： 19892809     DOI： 10.1093/qjmed/hcp159

Source DB:  PubMed          Journal:  QJM        ISSN： 1460-2393


  15 in total

1.  A tale from the Crypt: splice variants of BK channels in colonic potassium secretion.

Authors:  Carlos A Flores; L Pablo Cid; Francisco V Sepúlveda
Journal:  J Physiol       Date:  2010-06-01       Impact factor: 5.182

2.  Aldosterone induces active K⁺ secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon.

Authors:  Satish K Singh; Bryan O'Hara; Jamilur R Talukder; Vazhaikkurichi M Rajendran
Journal:  Am J Physiol Cell Physiol       Date:  2012-02-08       Impact factor: 4.249

Review 3.  The LRRC family of BK channel regulatory subunits: potential roles in health and disease.

Authors:  Vivian Gonzalez-Perez; Yu Zhou; Matthew A Ciorba; Christopher J Lingle
Journal:  J Physiol       Date:  2022-01-24       Impact factor: 5.182

Review 4.  Hyperkalemia in patients undergoing hemodialysis: Its pathophysiology and management.

Authors:  Shigeru Shibata; Shunya Uchida
Journal:  Ther Apher Dial       Date:  2021-08-31       Impact factor: 2.195

5.  Potassium channels in intestinal epithelial cells and their pharmacological modulation: a systematic review.

Authors:  Dina Cosme; Maria Manuela Estevinho; Florian Rieder; Fernando Magro
Journal:  Am J Physiol Cell Physiol       Date:  2020-12-16       Impact factor: 4.249

Review 6.  Non-systemic drugs: a critical review.

Authors:  Dominique Charmot
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

7.  Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.

Authors:  Vivian Gonzalez-Perez; Pedro L Martinez-Espinosa; Monica Sala-Rabanal; Nikhil Bharadwaj; Xiao-Ming Xia; Albert C Chen; David Alvarado; Jenny K Gustafsson; Hongzhen Hu; Matthew A Ciorba; Christopher J Lingle
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-19       Impact factor: 12.779

8.  Hypokalemia Associated with Colonic Pseudo-Obstruction (Ogilvie's Syndrome).

Authors:  Naseem Sunnoqrot; Robert F Reilly
Journal:  Case Rep Nephrol Dial       Date:  2015-05-28

9.  Multiple mineralocorticoid response elements localized in different introns regulate intermediate conductance K+ (Kcnn4) channel expression in the rat distal colon.

Authors:  Bryan O'Hara; Diego Alvarez de la Rosa; Vazhaikkurichi M Rajendran
Journal:  PLoS One       Date:  2014-06-05       Impact factor: 3.240

Review 10.  Potassium Metabolism and Management in Patients with CKD.

Authors:  Shinsuke Yamada; Masaaki Inaba
Journal:  Nutrients       Date:  2021-05-21       Impact factor: 5.717
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