OBJECTIVES: The purpose of this study was to examine the association of pericardial fat with the presence of coronary plaques. BACKGROUND: Waist circumference, reflecting abdominal obesity, is a risk factor of metabolic syndrome and coronary artery disease (CAD). Adipose tissue secretes many factors implicated in atherogenesis, however, the role of pericardial fat (ectopic visceral fat around coronary arteries) in the pathogenesis of CAD is not clear. METHODS: We measured total pericardial fat volume (PFV) and determined presence and characteristics of coronary plaques using 64-slice computed tomography in 171 consecutive patients suspected of CAD (101 men; mean age, 66+/-11 years, +/-SD). RESULTS: PFV correlated with age (p<0.05), body mass index (p<0.05), waist circumference (p<0.01), and high-density lipoprotein cholesterol (p<0.01) by multivariate regression analysis. PFV was significantly larger in patients with coronary plaques, even nonstenotic or noncalcified ones, than those without plaques (any plaques, n=123; 201+/-71cm(3), nonstenotic plaques, n=51; 192+/-63, noncalcified plaques, n=32; 196+/-56 vs. no plaque, n=48; 144+/-45, p<0.001, respectively). Multivariate backward logistic regression analysis demonstrated that PFV, but not waist circumference, significantly associated with the presence of any coronary plaques (odds ratio [OR]; 2.876, 95% confidence interval [95% CI]; 1.614-5.125, p<0.001), nonstenotic plaques confirmed by coronary angiography (OR; 3.423, 95% CI; 1.764-6.642, p<0.001), and noncalcified plaques (OR; 3.316, 95% CI; 1.435-7.661, p<0.01). CONCLUSIONS: PFV correlated significantly with the presence of nonstenotic and noncalcified coronary plaques assessed by multislice computed tomography. Pericardial fat is more highly associated with early development of CAD than simple anthropometric measures of abdominal obesity. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVES: The purpose of this study was to examine the association of pericardial fat with the presence of coronary plaques. BACKGROUND: Waist circumference, reflecting abdominal obesity, is a risk factor of metabolic syndrome and coronary artery disease (CAD). Adipose tissue secretes many factors implicated in atherogenesis, however, the role of pericardial fat (ectopic visceral fat around coronary arteries) in the pathogenesis of CAD is not clear. METHODS: We measured total pericardial fat volume (PFV) and determined presence and characteristics of coronary plaques using 64-slice computed tomography in 171 consecutive patients suspected of CAD (101 men; mean age, 66+/-11 years, +/-SD). RESULTS:PFV correlated with age (p<0.05), body mass index (p<0.05), waist circumference (p<0.01), and high-density lipoprotein cholesterol (p<0.01) by multivariate regression analysis. PFV was significantly larger in patients with coronary plaques, even nonstenotic or noncalcified ones, than those without plaques (any plaques, n=123; 201+/-71cm(3), nonstenotic plaques, n=51; 192+/-63, noncalcified plaques, n=32; 196+/-56 vs. no plaque, n=48; 144+/-45, p<0.001, respectively). Multivariate backward logistic regression analysis demonstrated that PFV, but not waist circumference, significantly associated with the presence of any coronary plaques (odds ratio [OR]; 2.876, 95% confidence interval [95% CI]; 1.614-5.125, p<0.001), nonstenotic plaques confirmed by coronary angiography (OR; 3.423, 95% CI; 1.764-6.642, p<0.001), and noncalcified plaques (OR; 3.316, 95% CI; 1.435-7.661, p<0.01). CONCLUSIONS:PFV correlated significantly with the presence of nonstenotic and noncalcified coronary plaques assessed by multislice computed tomography. Pericardial fat is more highly associated with early development of CAD than simple anthropometric measures of abdominal obesity. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: Jasmin Divers; Lynne E Wagenknecht; Donald W Bowden; J Jeffrey Carr; R Caresse Hightower; Thomas C Register; Jianzhao Xu; Carl D Langefeld; Barry I Freedman Journal: J Clin Endocrinol Metab Date: 2010-09-01 Impact factor: 5.958
Authors: Haim Shmilovich; Damini Dey; Victor Y Cheng; Ronak Rajani; Ryo Nakazato; Yuka Otaki; Rine Nakanishi; Piotr J Slomka; Louise E J Thomson; Sean W Hayes; John D Friedman; Heidi Gransar; Nathan D Wong; Leslee J Shaw; Matthew Budoff; Alan Rozanski; Daniel S Berman Journal: Am J Cardiol Date: 2011-08-30 Impact factor: 2.778
Authors: Kelly J Shields; Emma Barinas-Mitchell; Matthew R Gingo; Ping Tepper; Bret H Goodpaster; Amy H Kao; Susan Manzi; Kim Sutton-Tyrrell Journal: Atherosclerosis Date: 2013-09-11 Impact factor: 5.162
Authors: Andrew H Talman; Peter J Psaltis; James D Cameron; Ian T Meredith; Sujith K Seneviratne; Dennis T L Wong Journal: Cardiovasc Diagn Ther Date: 2014-12
Authors: A D Dobrian; M A Hatcher; J J Brotman; E V Galkina; P Taghavie-Moghadam; H Pei; B A Haynes; J L Nadler Journal: J Endocrinol Date: 2015-08-18 Impact factor: 4.286
Authors: Vincent Dunet; François Feihl; Amin Dabiri; Gilles Allenbach; Bernard Waeber; Raphaël Heinzer; John O Prior Journal: Eur J Nucl Med Mol Imaging Date: 2015-08-19 Impact factor: 9.236