OBJECTIVES: To assess the efficacy of antitubercular treatment on the uterine cavity in infertile women diagnosed with genital tuberculosis using second-look hysteroscopy. METHODS: A total of 70 women with genital tuberculosis who underwent second-look hysteroscopy were enrolled in the study. They were started on antitubercular drugs and followed up after 6 months of therapy with second-look hysteroscopy. McNemar's chi(2) test was used to compare the hysteroscopy findings before and after antitubercular treatment. RESULTS: Antitubercular treatment improved hysteroscopy findings in women with thin or flimsy adhesions (grade I), singular dense adhesions (grade II), and occluding adhesions at the internal os (grade IIa) (P<0.01). Patients with extensive adhesions, extensive endometrial scarring, fibrosis, and a tubular cavity showed no improvement after antitubercular treatment. Mean endometrial thickness of the 70 patients on day 21 prior to starting drug therapy was 6.8mm, which increased to 8.1mm after 6 months of treatment. CONCLUSION: Considering the exorbitant cost of assisted reproductive technology in low-resource countries, it is necessary to consider reassessment of the uterine cavity prior to beginning such treatment. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
OBJECTIVES: To assess the efficacy of antitubercular treatment on the uterine cavity in infertilewomen diagnosed with genital tuberculosis using second-look hysteroscopy. METHODS: A total of 70 women with genital tuberculosis who underwent second-look hysteroscopy were enrolled in the study. They were started on antitubercular drugs and followed up after 6 months of therapy with second-look hysteroscopy. McNemar's chi(2) test was used to compare the hysteroscopy findings before and after antitubercular treatment. RESULTS: Antitubercular treatment improved hysteroscopy findings in women with thin or flimsy adhesions (grade I), singular dense adhesions (grade II), and occluding adhesions at the internal os (grade IIa) (P<0.01). Patients with extensive adhesions, extensive endometrial scarring, fibrosis, and a tubular cavity showed no improvement after antitubercular treatment. Mean endometrial thickness of the 70 patients on day 21 prior to starting drug therapy was 6.8mm, which increased to 8.1mm after 6 months of treatment. CONCLUSION: Considering the exorbitant cost of assisted reproductive technology in low-resource countries, it is necessary to consider reassessment of the uterine cavity prior to beginning such treatment. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: M M Sankar; P Kumar; A Munawwar; M Kumar; J Singh; A Singh; D Parashar; N Malhotra; S Duttagupta; S Singh Journal: Eur J Clin Microbiol Infect Dis Date: 2012-09-30 Impact factor: 3.267