Literature DB >> 19892249

Microcirculatory dysfunction in sepsis.

David J Lundy1, Stephen Trzeciak.   

Abstract

This article discusses the role of microcirculatory dysfunction in the pathophysiology of sepsis, reviewing the role of the endothelium in modulating microcirculatory flow, discussing the function of nitric oxide in mediating microcirculatory blood flow, and outlining means of evaluating microcirculatory function in septic patients. Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed.

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Year:  2009        PMID： 19892249     DOI： 10.1016/j.ccc.2009.06.002

Source DB:  PubMed          Journal:  Crit Care Clin        ISSN： 0749-0704            Impact factor:   3.598


  13 in total

Review 1.  Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.

Authors:  Philip R Mayeux; Lee Ann MacMillan-Crow
Journal:  Pharmacol Ther       Date:  2012-01-16       Impact factor: 12.310

2.  Rolipram improves renal perfusion and function during sepsis in the mouse.

Authors:  Joseph H Holthoff; Zhen Wang; Naeem K Patil; Neriman Gokden; Philip R Mayeux
Journal:  J Pharmacol Exp Ther       Date:  2013-09-09       Impact factor: 4.030

3.  Primary outcomes for resuscitation science studies: a consensus statement from the American Heart Association.

Authors:  Lance B Becker; Tom P Aufderheide; Romergryko G Geocadin; Clifton W Callaway; Ronald M Lazar; Michael W Donnino; Vinay M Nadkarni; Benjamin S Abella; Christophe Adrie; Robert A Berg; Raina M Merchant; Robert E O'Connor; David O Meltzer; Margo B Holm; William T Longstreth; Henry R Halperin
Journal:  Circulation       Date:  2011-10-03       Impact factor: 29.690

4.  Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury.

Authors:  Joseph H Holthoff; Zhen Wang; Kathryn A Seely; Neriman Gokden; Philip R Mayeux
Journal:  Kidney Int       Date:  2011-10-05       Impact factor: 10.612

5.  Activated protein C induces endoplasmic reticulum stress and attenuates lipopolysaccharide-induced apoptosis mediated by glycogen synthase kinase-3β.

Authors:  Liang Luo; Tangfeng Lv; Qian Wang; Ting Zhang; Xiaoling Gu; Feng Xu; Yong Song
Journal:  Mediators Inflamm       Date:  2012-05-28       Impact factor: 4.711

6.  Early neurovascular uncoupling in the brain during community acquired pneumonia.

Authors:  Bernhard Rosengarten; Dennis Krekel; Stefan Kuhnert; Richard Schulz
Journal:  Crit Care       Date:  2012-12-12       Impact factor: 9.097

Review 7.  Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.

Authors:  Tuhin K Roy; Timothy W Secomb
Journal:  Microcirculation       Date:  2020-12-21       Impact factor: 2.679

Review 8.  Systemic and renal oxidative stress in the pathogenesis of hypertension: modulation of long-term control of arterial blood pressure by resveratrol.

Authors:  Shereen M Hamza; Jason R B Dyck
Journal:  Front Physiol       Date:  2014-08-05       Impact factor: 4.566

Review 9.  Microcirculatory dysfunction and tissue oxygenation in critical illness.

Authors:  L Østergaard; A Granfeldt; N Secher; A Tietze; N K Iversen; M S Jensen; K K Andersen; K Nagenthiraja; P Gutiérrez-Lizardi; K Mouridsen; S N Jespersen; E K Tønnesen
Journal:  Acta Anaesthesiol Scand       Date:  2015-07-07       Impact factor: 2.105

10.  Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.

Authors:  Stanka Mihaylova; Anke Killian; Konstantin Mayer; Soni Savai Pullamsetti; Ralph Schermuly; Bernhard Rosengarten
Journal:  J Neuroinflammation       Date:  2012-07-25       Impact factor: 8.322
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